Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4618060 | 0.88 | GAA (0.47) | PRKCA | |
| SCHEMBL4619070 | 0.85 | LMNA (0.43) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2156979 | 0.84 | PRKCA (0.44) | SMN1; SMN2PRKCANPC1RAB9AMAPT | |
| SCHEMBL12395267 | 0.84 | MAPT (0.46) | SMN1; SMN2PRKCANPC1RAB9AKMT2A | |
| SCHEMBL4618449 | 0.79 | KMT2A (0.41) | SMN1; SMN2NPC1RAB9ATDP1KMT2A | |
| SCHEMBL2156976 | 0.75 | APEX1 (0.44) | KMT2AMAPK1 | |
| SCHEMBL12395266 | 0.75 | SMN1; SMN2 (0.42) | SMN1; SMN2TDP1KMT2AMAPTMAPK1 | |
| SCHEMBL4619703 | 0.74 | ALDH1A1 (0.42) | SMN1; SMN2PRKCATDP1KMT2AMAPT | |
| SCHEMBL2156506 | 0.74 | FOLH1 (0.41) | KMT2AMAPTHIF1A | |
| SCHEMBL2156923 | 0.71 | TSHR (0.39) | SMN1; SMN2PRKCAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888555-A2 | SUBSTITUTED BENZO-CONDENSED CYCLOHEXANONE DERIVATIVES AND THE USE THEREOF FOR MEDICAMENT PRODUCTION | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122771-A2 | SUBSTITUTED BENZO-CONDENSED CYCLOHEXANONE DERIVATIVES AND THE USE THEREOF FOR MEDICAMENT PRODUCTION | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |
| EP-1888555-A2 | SUBSTITUTED BENZO-CONDENSED CYCLOHEXANONE DERIVATIVES AND THE USE THEREOF FOR MEDICAMENT PRODUCTION | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006122771-A2 | SUBSTITUTED BENZO-CONDENSED CYCLOHEXANONE DERIVATIVES AND THE USE THEREOF FOR MEDICAMENT PRODUCTION | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | disclosed |