Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4711831 | 0.75 | TDP1 (0.49) | KDM4EALDH1A1CYP3A4HPGDSMN1; SMN2 | |
| SCHEMBL4621133 | 0.75 | KDM4E (0.34) | KDM4EALDH1A1CYP3A4HPGDSMN1; SMN2 | |
| SCHEMBL2492937 | 0.73 | KDM4E (0.40) | KDM4EALDH1A1CYP3A4HPGDSMN1; SMN2 | |
| SCHEMBL4619990 | 0.71 | KDM4E (0.44) | KDM4EALDH1A1CYP3A4HPGDSMN1; SMN2 | |
| SCHEMBL24727379 | 0.71 | F2 (0.36) | KDM4EALDH1A1HSD17B10TDP1L3MBTL1 | |
| SCHEMBL21663105 | 0.69 | PTGS2 (0.37) | KDM4EALDH1A1CYP3A4HPGDSMN1; SMN2 | |
| SCHEMBL27599794 | 0.69 | KDM4E (0.50) | KDM4EALDH1A1CYP3A4HPGDSMN1; SMN2 | |
| SCHEMBL341861 | 0.68 | CYP1A2 (0.41) | KDM4EALDH1A1CYP3A4HPGDSMN1; SMN2 | |
| SCHEMBL20068157 | 0.66 | ALDH1A1 (0.52) | KDM4EALDH1A1CYP3A4HPGDSMN1; SMN2 | |
| SCHEMBL18330473 | 0.66 | KDM4E (0.45) | KDM4EALDH1A1CYP3A4HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885709-A2 | BENZOFURAN DERIVATIVES WITH THERAPEUTIC ACTIVITIES | Pharmos Corporation (US) | 2008-02-13 | — | — | EP | claimed |
| WO-2006129318-A2 | BENZOFURAN DERIVATIVES WITH THERAPEUTIC ACTIVITIES | PHARMOS CORPORATION (US) | 2006-12-07 | — | — | WO | claimed |
| EP-1885709-A2 | BENZOFURAN DERIVATIVES WITH THERAPEUTIC ACTIVITIES | Pharmos Corporation (US) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006129318-A2 | BENZOFURAN DERIVATIVES WITH THERAPEUTIC ACTIVITIES | PHARMOS CORPORATION (US) | 2006-12-07 | — | — | WO | disclosed |