Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4619951 | 1.00 | EPHX2 (0.41) | EPHX2NR1H4TRPV1 | |
| SCHEMBL4620794 | 0.85 | CYP19A1 (0.42) | NR1H4 | |
| SCHEMBL2204827 | 0.84 | EPHX2 (0.48) | EPHX2NR1H4TRPV1 | |
| SCHEMBL2208558 | 0.84 | EPHX2 (0.48) | EPHX2NR1H4TRPV1 | |
| SCHEMBL2205140 | 0.84 | EPHX2 (0.48) | EPHX2NR1H4TRPV1 | |
| SCHEMBL4619905 | 0.81 | GPR119 (0.34) | EPHX2TRPV1 | |
| SCHEMBL4673169 | 0.80 | EPHX2 (0.44) | EPHX2NR1H4TRPV1 | |
| SCHEMBL4620657 | 0.79 | TRPV1 (0.40) | TRPV1 | |
| SCHEMBL4619894 | 0.76 | FAAH (0.39) | EPHX2 | |
| SCHEMBL4621118 | 0.75 | TRPV1 (0.46) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888542-A1 | SUBSTITUTED SPIRO-COMPOUNDS AND THE USE THEREOF FOR PRODUCING MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006136245-A1 | SUBSTITUTED SPIRO-COMPOUNDS AND THE USE THEREOF FOR PRODUCING MEDICAMENTS | Grünenthal GmbH (DE) | 2006-12-28 | — | — | WO | claimed |
| EP-1888542-A1 | SUBSTITUTED SPIRO-COMPOUNDS AND THE USE THEREOF FOR PRODUCING MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006136245-A1 | SUBSTITUTED SPIRO-COMPOUNDS AND THE USE THEREOF FOR PRODUCING MEDICAMENTS | Grünenthal GmbH (DE) | 2006-12-28 | — | — | WO | disclosed |