Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | FABP4 | P15090 | 1/20 | 0.58 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1259799 | 0.86 | CYP1A2 (0.57) | TSHRKDM4EHPGDCYP1A2CYP2C19 | |
| SCHEMBL9819126 | 0.86 | CYP3A4 (0.63) | CYP1A2CYP2C19MEN1KMT2AHTT | |
| SCHEMBL21972564 | 0.85 | ALDH1A1 (0.62) | TSHRKDM4EFABP4SLC2A1MEN1 | |
| SCHEMBL20219039 | 0.82 | TSHR (0.76) | TSHRKDM4EFABP4SLC2A1HPGD | |
| SCHEMBL11140544 | 0.82 | ALDH1A1 (0.69) | TSHRHPGDCYP1A2CYP2C19MEN1 | |
| SCHEMBL1259319 | 0.82 | CYP1A2 (0.57) | TSHRKDM4EHPGDCYP1A2CYP2C19 | |
| SCHEMBL31023418 | 0.81 | TSHR (0.73) | TSHRKDM4EFABP4SLC2A1HPGD | |
| SCHEMBL4002460 | 0.81 | TSHR (0.73) | TSHRKDM4EFABP4SLC2A1HPGD | |
| SCHEMBL1618221 | 0.80 | ALDH1A1 (0.64) | TSHRKDM4EHPGDCYP1A2CYP2C19 | |
| SCHEMBL7933287 | 0.80 | TSHR (0.71) | TSHRKDM4EFABP4SLC2A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1883621-A2 | METHODS OF PREPARING 3-CYANO-QUINOLINES AND INTERMEDIATES MADE THEREBY | Wyeth (US) | 2008-02-06 | — | — | EP | disclosed |
| US-7297795-B2 | Process for preparation of 4-amino-3-quinolinecarbonitriles | WYETH HOLDINGS CORPORATION (US) | 2007-11-20 | — | — | US | disclosed |
| US-20060270669-A1 | Method of preparing 3-cyano-quinolines and intermediates made thereby | WYETH | 2006-11-30 | — | — | US | disclosed |
| WO-2006127205-A2 | METHODS OF PREPARING 3-CYANO-QUINOLINES AND INTERMEDIATES MADE THEREBY | WYETH (US) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270669-A1 | Method of preparing 3-cyano-quinolines and intermediates made thereby | CNP, PPP4C, PTMS | TSHR 3714/4885KDM4E 490/4885FABP4 4311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.