Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 7/20 | 0.41 |
| ▸ | TFPI2 | P48307 | 8/20 | 0.41 |
| ▸ | NPY4R | P50391 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31435509 | 0.77 | TFPI2 (0.58) | ELANETFPI2NPY4RNOTUMTSHR | |
| SCHEMBL6089590 | 0.77 | NOTUM (0.58) | TFPI2NPY4RNOTUMTSHRRAB9A | |
| SCHEMBL7024843 | 0.77 | TFPI2 (0.58) | ELANETFPI2NPY4RNOTUMTSHR | |
| SCHEMBL6230903 | 0.73 | NOTUM (0.38) | NOTUMTSHRRAB9AL3MBTL1 | |
| SCHEMBL15515985 | 0.73 | NOTUM (0.34) | NOTUMTSHRRAB9AL3MBTL1 | |
| SCHEMBL14220747 | 0.72 | TFPI2 (0.62) | ELANETFPI2NPY4RTSHRRAB9A | |
| SCHEMBL4622821 | 0.72 | RAB9A (0.66) | TFPI2NPY4RNOTUMTSHRRAB9A | |
| SCHEMBL1206513 | 0.70 | BUB1 (0.39) | NOTUML3MBTL1 | |
| SCHEMBL25382918 | 0.69 | TFPI2 (0.43) | ELANETFPI2NPY4RGRIN2B | |
| SCHEMBL14663394 | 0.68 | OPRM1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1905762-A1 | PYRAZOLONE DERIVATIVE | Genecare Research Institute Co., Ltd (JP) | 2008-04-02 | — | — | EP | claimed |
| EP-1900728-A1 | PHARMACEUTICAL COMPOSITION COMPRISING PYRAZOLONE DERIVATIVE | Genecare Research Institute Co., Ltd (JP) | 2008-03-19 | — | — | EP | claimed |
| EP-1905762-A1 | PYRAZOLONE DERIVATIVE | Genecare Research Institute Co., Ltd (JP) | 2008-04-02 | — | — | EP | disclosed |
| EP-1900728-A1 | PHARMACEUTICAL COMPOSITION COMPRISING PYRAZOLONE DERIVATIVE | Genecare Research Institute Co., Ltd (JP) | 2008-03-19 | — | — | EP | disclosed |