Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TFPI2 | P48307 | 1/20 | 0.58 |
| ▸ | NPY4R | P50391 | 1/20 | 0.58 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.49 |
| ▸ | HTR3B | O95264 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.49 |
| ▸ | ELANE | P08246 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31435509 | 1.00 | TFPI2 (0.58) | TFPI2NPY4RNOTUMTSHRRAB9A | |
| SCHEMBL15134007 | 0.77 | PRKCI (0.45) | TFPI2NPY4RELANE | |
| SCHEMBL25382918 | 0.77 | TFPI2 (0.43) | TFPI2NPY4RELANEHSD17B10TP53 | |
| SCHEMBL14220747 | 0.77 | TFPI2 (0.62) | TFPI2NPY4RTSHRRAB9AELANE | |
| SCHEMBL4620387 | 0.77 | ELANE (0.41) | TFPI2NPY4RNOTUMTSHRRAB9A | |
| SCHEMBL1151123 | 0.77 | NOTUM (0.70) | TFPI2NPY4RNOTUMTSHRRAB9A | |
| SCHEMBL10477477 | 0.77 | NOTUM (0.70) | TFPI2NPY4RNOTUMTSHRRAB9A | |
| SCHEMBL2078057 | 0.76 | NOTUM (0.59) | TFPI2NPY4RNOTUMTSHRRAB9A | |
| SCHEMBL9570724 | 0.76 | ADRA1A (0.46) | TFPI2NPY4RNOTUMTSHRRAB9A | |
| SCHEMBL931955 | 0.75 | TSHR (0.69) | TFPI2NPY4RNOTUMTSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276720-A2 | 2-ACYL INDOL DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS | ASTA Medica AG (DE) | 2003-01-22 | — | — | EP | disclosed |
| WO-2001082909-A2 | 2-ACYL INDOL DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS | BAXTER HEALTHCARE SA (DE) | 2001-11-08 | — | — | WO | disclosed |