Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | SREBF2 | Q12772 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | HPGD | P15428 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | GLA | P06280 | 3/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | ILK | Q13418 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4622103 | 0.89 | LMNA (0.35) | NPC1LMNASREBF2MAPTHPGD | |
| SCHEMBL4619193 | 0.88 | LMNA (0.34) | NPC1LMNASREBF2MAPTHPGD | |
| SCHEMBL4621808 | 0.88 | SREBF2 (0.34) | SREBF2MAPTCTSSCTSKILK | |
| SCHEMBL4618747 | 0.88 | LMNA (0.34) | NPC1LMNASREBF2MAPTHPGD | |
| SCHEMBL4089067 | 0.88 | NPC1 (0.34) | RORCNPC1ALDH1A1MAPTHPGD | |
| SCHEMBL4083068 | 0.83 | PIK3CD (0.33) | RORCNPC1ALDH1A1MAPTHPGD | |
| SCHEMBL4085450 | 0.79 | KDM4E (0.36) | NPC1LMNAALDH1A1MAPTHPGD | |
| SCHEMBL4094643 | 0.79 | HDAC6 (0.42) | MEN1KMT2A | |
| SCHEMBL4087175 | 0.77 | CASP3 (0.34) | NPC1ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL4093006 | 0.77 | MEN1 (0.33) | RORCLMNAALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1897880-A1 | 1,3-BENZOTHIAZINONE DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2008-03-12 | — | — | EP | claimed |