Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 3/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | ILK | Q13418 | 1/20 | 0.33 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4619193 | 0.99 | LMNA (0.34) | LMNASREBF2MAPTKDM4EATM | |
| SCHEMBL4618747 | 0.99 | LMNA (0.34) | LMNASREBF2MAPTKDM4EATM | |
| SCHEMBL4621029 | 0.89 | RORC (0.38) | LMNASREBF2MAPTKDM4EATM | |
| SCHEMBL4094643 | 0.89 | HDAC6 (0.42) | PPARACASP3SENP8SENP7SENP6 | |
| SCHEMBL4621808 | 0.88 | SREBF2 (0.34) | SREBF2MAPTCTSSCTSKILK | |
| SCHEMBL4087175 | 0.87 | CASP3 (0.34) | MAPTKDM4EPPARACASP3SENP8 | |
| SCHEMBL4093006 | 0.87 | MEN1 (0.33) | LMNAMAPTKDM4EATMPPARA | |
| Potassium Ion SCHEMBL4088703 | 0.87 | MEN1 (0.33) | LMNAMAPTKDM4EATMPPARA | |
| SCHEMBL4085450 | 0.87 | KDM4E (0.36) | LMNAMAPTKDM4ECASP3SENP8 | |
| SCHEMBL4082600 | 0.86 | EGFR (0.38) | MAPTKDM4EPPARACASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1897880-A1 | 1,3-BENZOTHIAZINONE DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2008-03-12 | — | — | EP | claimed |
| EP-1897880-A1 | 1,3-BENZOTHIAZINONE DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2008-03-12 | — | — | EP | disclosed |