Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | TLR4 | O00206 | 2/20 | 0.46 |
| ▸ | TLR2 | O60603 | 2/20 | 0.46 |
| ▸ | FBP1 | P09467 | 3/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 10/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 9/20 | 0.41 |
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.41 |
| ▸ | CCR6 | P51684 | 2/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13915431 | 1.00 | RXRA (0.50) | RXRATLR4TLR2FBP1PRMT1 | |
| SCHEMBL28409564 | 0.83 | RXRA (0.50) | RXRATLR4TLR2FBP1PRMT1 | |
| SCHEMBL28409911 | 0.83 | RXRA (0.50) | RXRATLR4TLR2FBP1PRMT1 | |
| SCHEMBL13979638 | 0.75 | MAPT (0.43) | RXRATLR4TLR2FBP1MAPT | |
| SCHEMBL4887026 | 0.75 | MAPT (0.43) | RXRATLR4TLR2FBP1MAPT | |
| SCHEMBL14178884 | 0.75 | MAPT (0.43) | RXRATLR4TLR2FBP1PRMT1 | |
| SCHEMBL6696894 | 0.73 | TDP1 (0.45) | RXRATLR4TLR2FBP1MAPT | |
| SCHEMBL6696898 | 0.73 | TDP1 (0.45) | RXRATLR4TLR2FBP1MAPT | |
| SCHEMBL2297146 | 0.73 | RXRA (0.58) | RXRATLR4TLR2FBP1PRMT1 | |
| SCHEMBL29742372 | 0.73 | RXRA (0.58) | RXRATLR4TLR2FBP1PRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075169-A2 | A PROCESS FOR THE PURIFICATION OF ROPINIROLE HYDROCHLORIDE | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2008-06-26 | — | — | WO | disclosed |
| US-20050192338-A1 | Process for the preparation of Ropinirole | CF PHARMA GYOGYSZERGYARTO KFT. (HU) | 2005-09-01 | — | — | US | disclosed |
| WO-2005080333-A1 | PROCESS FOR PURIFICATION OF ROPINIROLE | TORRENT PHARMACEUTICALS LTD (IN) | 2005-09-01 | — | — | WO | disclosed |
| EP-1568689-A1 | Process for the preparation of the 2-oxoindole derivative, Ropinirole | Helm AG (DE) | 2005-08-31 | — | — | EP | disclosed |
| EP-0300614-B1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED INDOLINONE DERIVATIVES | SMITH KLINE FRENCH LAB (GB) | 1993-08-25 | — | — | EP | disclosed |
| US-4997954-A | Process for preparing substituted isoindolinone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-03-05 | — | — | US | disclosed |
| EP-0300614-A1 | Process for the preparation of substituted indolinone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-01-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050192338-A1 | Process for the preparation of Ropinirole | PRLHR, ADCYAP1R1, QDPR | RXRA 3246/4885TLR4 3806/4885TLR2 4443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.