Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15961771 | 0.80 | MAPT (0.40) | MAPTLMNAALDH1A1RAB9AKDM4E | |
| SCHEMBL10601676 | 0.78 | MAPT (0.42) | MAPTLMNAALDH1A1RAB9AKDM4E | |
| SCHEMBL28629984 | 0.78 | MAPT (0.38) | MAPTLMNAALDH1A1RAB9AKDM4E | |
| Bromide SCHEMBL27390508 | 0.77 | ESR2 (0.36) | CA9CA12CA1CA2 | |
| SCHEMBL29113469 | 0.74 | ALDH1A1 (0.39) | MAPTLMNAALDH1A1RAB9AKDM4E | |
| SCHEMBL28666103 | 0.74 | CYP11B2 (0.49) | MAPTALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL28662569 | 0.74 | MAOA (0.41) | MAPTLMNAALDH1A1KDM4ENPC1 | |
| SCHEMBL626635 | 0.73 | MAOA (0.44) | MAPTLMNAALDH1A1RAB9AKDM4E | |
| SCHEMBL15170872 | 0.72 | MAPT (0.36) | MAPTLMNAALDH1A1RAB9AKDM4E | |
| Hydrochloric Acid SCHEMBL4604224 | 0.71 | MAOA (0.42) | TSHRPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109810111-A | A kind of pyrazolone miazines compound, preparation method and application | 上海医药集团股份有限公司 | 2019-05-28 | — | — | CN | disclosed |
| EP-1883632-A1 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | Amgen Inc. (US) | 2008-02-06 | — | — | EP | disclosed |
| EP-1828185-A2 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006116563-A1 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2006-11-02 | — | — | WO | disclosed |
| WO-2006068826-A2 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-06-29 | — | — | WO | disclosed |