Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.36 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12391039 | 0.84 | ASIC3 (0.50) | ASIC3HAO1L3MBTL1LMNAMAPT | |
| SCHEMBL8873911 | 0.82 | L3MBTL1 (0.50) | ASIC3GRM5L3MBTL1KMT2AFFAR1 | |
| SCHEMBL13597757 | 0.82 | HRH3 (0.45) | HDAC8HAO1GRM5LMNAMAPT | |
| SCHEMBL25234950 | 0.80 | SLC2A4 (0.42) | ASIC3MAPTFFAR1HTT | |
| SCHEMBL487465 | 0.77 | MAPT (0.56) | ASIC3HAO1L3MBTL1LMNAMAPT | |
| SCHEMBL4863464 | 0.76 | CYP2A6 (0.50) | GRM5 | |
| Methyl Alcohol SCHEMBL28280712 | 0.76 | GRM5 (0.52) | HDAC8HAO1GRM5LMNAMAPT | |
| SCHEMBL14268091 | 0.76 | ASIC3 (0.49) | ASIC3HAO1GRM5L3MBTL1LMNA | |
| SCHEMBL12711667 | 0.76 | APP (0.47) | ASIC3HAO1L3MBTL1LMNAMAPT | |
| SCHEMBL1571249 | 0.74 | ASIC3 (0.44) | ASIC3HAO1L3MBTL1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |
| EP-1144423-B1 | BIS-TERPYRIDINE-PLATINUM(II) COMPLEXES | ISIS INNOVATION (GB) | 2003-10-22 | — | — | EP | disclosed |
| EP-1144423-A1 | BIS-TERPYRIDINE-PLATINUM(II) COMPLEXES | ISIS INNOVATION LIMITED (GB) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000043405-A1 | BIS-TERPYRIDINE-PLATINUM(II) COMPLEXES | ISIS INNOVATION LIMITED (GB) | 2000-07-27 | — | — | WO | disclosed |