Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 3/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ESRRA | P11474 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27686098 | 0.86 | ELANE (0.59) | ELANECA2KDM1AATMMAPT | |
| SCHEMBL2540263 | 0.83 | ELANE (0.56) | ELANECA2KDM1ATDP1L3MBTL1 | |
| SCHEMBL17355754 | 0.82 | ELANE (0.54) | ELANECA2KDM1APOLBMAPT | |
| SCHEMBL5907902 | 0.81 | ELANE (0.53) | ELANECA2KDM1AMAPTTDP1 | |
| SCHEMBL26064706 | 0.81 | ESR1 (0.41) | ELANEESR1NR1H4ATMPOLB | |
| SCHEMBL4061539 | 0.80 | ELANE (0.65) | ELANECA2KDM1APOLBMAPT | |
| SCHEMBL4061370 | 0.80 | ELANE (0.81) | ELANECA2KDM1AMAPTTDP1 | |
| SCHEMBL4743520 | 0.80 | ELANE (0.51) | ELANECA2KDM1ANR1H4ATM | |
| SCHEMBL19558305 | 0.79 | ELANE (0.56) | ELANECA2ESR1 | |
| SCHEMBL4641620 | 0.79 | ELANE (0.54) | ELANECA2KDM1ANR1H4ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384983-B2 | Inhibitor of monoamine uptake | ELI LILLY AND COMPANY (US) | 2008-06-10 | — | — | US | disclosed |
| EP-1379492-B1 | INHIBITOR OF MONOAMINE UPTAKE | LILLY CO ELI (US) | 2008-05-21 | — | — | EP | disclosed |
| US-20050209341-A1 | Inhibitor of monoamine uptake | MATTIUZ EDWARD L | 2005-09-22 | — | — | US | disclosed |
| US-20040082666-A1 | Inhibitor of monoamine uptake | MATTIUZ EDWARD LOUIS (US) | 2004-04-29 | — | — | US | disclosed |
| EP-1379492-A1 | INHIBITOR OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002070457-A1 | INHIBITOR OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2002-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082666-A1 | Inhibitor of monoamine uptake | SLC18A2, SLC6A2, SLC18A3 | ELANE 4718/4885CA2 2744/4885ESR1 3837/4885 |
| US-20050209341-A1 | Inhibitor of monoamine uptake | SLC18A2, SLC6A2, SLC18A3 | ELANE 4718/4885CA2 2744/4885ESR1 3837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.