Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2245812 | 0.91 | HDAC1 (0.37) | MMP2MMP9ALDH1A1MAPTHPGD | |
| SCHEMBL2245867 | 0.90 | MMP2 (0.40) | MMP2MMP9ALDH1A1MAPTHPGD | |
| SCHEMBL2249780 | 0.89 | MMP12 (0.36) | MMP2ALDH1A1MAPTHPGDOPRD1 | |
| SCHEMBL2245162 | 0.87 | ERN1 (0.36) | MMP2MMP9ALDH1A1MAPTHPGD | |
| SCHEMBL2244927 | 0.87 | PPARG (0.37) | MMP2MMP9ALDH1A1MAPTHPGD | |
| SCHEMBL2247320 | 0.86 | MMP2 (0.35) | MMP2MMP9ALDH1A1MAPTHPGD | |
| SCHEMBL2245193 | 0.86 | MMP2 (0.43) | MMP2MMP9ALDH1A1MAPTHPGD | |
| SCHEMBL2247635 | 0.84 | MCHR1 (0.36) | MMP2MMP9ALDH1A1MAPTHPGD | |
| SCHEMBL4621840 | 0.83 | KMT2A (0.37) | ALDH1A1 | |
| SCHEMBL2244641 | 0.82 | MMP2 (0.38) | MMP2ALDH1A1HPGDTRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902014-A2 | GLUTAMATE AGGRECANASE INHIBITORS | Wyeth (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007008994-A2 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2007-01-18 | — | — | WO | disclosed |