Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 4/20 | 0.65 |
| ▸ | TTK | P33981 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | BMPR1B | O00238 | 3/20 | 0.49 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.49 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.49 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.49 |
| ▸ | USP7 | Q93009 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 3/20 | 0.47 |
| ▸ | MERTK | Q12866 | 3/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2225948 | 0.81 | FYN (0.76) | FYNCHEK2CHEK1BMPR1BBMPR1A | |
| SCHEMBL4621190 | 0.80 | FYN (0.80) | FYNCHEK2CHEK1TGFBR1 | |
| SCHEMBL13968136 | 0.80 | FYN (0.70) | FYNTTKCHEK2BMPR1BBMPR1A | |
| SCHEMBL18613238 | 0.79 | FYN (1.00) | FYNCHEK2CHEK1BMPR1AACVRL1 | |
| SCHEMBL1679554 | 0.76 | PRKD3 (0.70) | FYNCHEK2CHEK1MAP4K4 | |
| SCHEMBL4620931 | 0.73 | FYN (0.65) | FYNACVR1TGFBR1 | |
| SCHEMBL6838760 | 0.71 | MERTK (0.60) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL2750178 | 0.70 | FYN (0.55) | FYNCHEK2BMPR1BBMPR1AACVRL1 | |
| SCHEMBL4621070 | 0.70 | FYN (0.53) | FYNCHEK2CHEK1BMPR1AACVRL1 | |
| SCHEMBL18616701 | 0.70 | BMPR1B (0.71) | FYNBMPR1BBMPR1AACVRL1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |