Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4622445 | 1.00 | ESR1 (0.52) | ESR1ESR2KMT2APTGS2MEN1 | |
| SCHEMBL4620299 | 0.91 | ALDH1A1 (0.42) | ESR1ESR2KMT2AMEN1CYP1A2 | |
| SCHEMBL517954 | 0.77 | ESR1 (0.68) | ESR1ESR2ALDH1A1LMNAMAPT | |
| SCHEMBL4622447 | 0.77 | MEN1 (0.46) | KMT2AMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4623273 | 0.77 | MEN1 (0.46) | KMT2AMEN1CYP1A2CYP3A4CYP2C9 | |
| Methylphenylsulfide SCHEMBL11437167 | 0.74 | KMT2A (0.39) | ESR1ESR2KMT2APTGS2MEN1 | |
| Methylphenylsulfide SCHEMBL1332325 | 0.74 | — | — | |
| Methylphenylsulfide SCHEMBL7584 | 0.74 | — | — | |
| Phosphine SCHEMBL15190577 | 0.74 | ESR1 (0.65) | ESR1ESR2ALDH1A1LMNAMAPT | |
| Methylphenylsulfide SCHEMBL4902407 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7446228-B2 | Thiophosphine compounds | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2008-11-04 | — | — | US | disclosed |
| US-7446228-B2 | Thiophosphine compounds | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2008-11-04 | — | — | US | disclosed |
| US-7446228-B2 | Thiophosphine compounds | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2008-11-04 | — | — | US | disclosed |
| US-7378556-B2 | Process for making thiophosphine compounds | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2008-05-27 | — | — | US | disclosed |
| US-7378556-B2 | Process for making thiophosphine compounds | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2008-05-27 | — | — | US | disclosed |
| US-7378556-B2 | Process for making thiophosphine compounds | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2008-05-27 | — | — | US | disclosed |
| EP-1608704-B1 | THIOPHOSPHINE COMPOUNDS AND METHOD OF MAKING POLYMERISABLE COMPOSITIONS CONTAINING THEM AND THEIR USE FOR MAKING OPHTALMIC LENSES | ESSILOR INT (FR) | 2008-03-19 | — | — | EP | disclosed |
| EP-1608704-B1 | THIOPHOSPHINE COMPOUNDS AND METHOD OF MAKING POLYMERISABLE COMPOSITIONS CONTAINING THEM AND THEIR USE FOR MAKING OPHTALMIC LENSES | ESSILOR INT (FR) | 2008-03-19 | — | — | EP | disclosed |
| US-20070232834-A1 | THIOPHOSPHINE COMPOUNDS AND METHODS OF MAKING POLYMERIZABLE COMPOSITIONS CONTAINING THEM AND THEIR USE FOR MAKING OPHTHALMIC LENSES | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2007-10-04 | — | — | US | disclosed |
| US-20070232834-A1 | THIOPHOSPHINE COMPOUNDS AND METHODS OF MAKING POLYMERIZABLE COMPOSITIONS CONTAINING THEM AND THEIR USE FOR MAKING OPHTHALMIC LENSES | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2007-10-04 | — | — | US | disclosed |
| US-20070232834-A1 | THIOPHOSPHINE COMPOUNDS AND METHODS OF MAKING POLYMERIZABLE COMPOSITIONS CONTAINING THEM AND THEIR USE FOR MAKING OPHTHALMIC LENSES | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2007-10-04 | — | — | US | disclosed |
| US-20070232835-A1 | THIOPHOSPHINE COMPOUNDS AND METHODS OF MAKING POLYMERIZABLE COMPOSITIONS CONTAINING THEM AND THEIR USE FOR MAKING OPHTHALMIC LENSES | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2007-10-04 | — | — | US | disclosed |
| US-20070232835-A1 | THIOPHOSPHINE COMPOUNDS AND METHODS OF MAKING POLYMERIZABLE COMPOSITIONS CONTAINING THEM AND THEIR USE FOR MAKING OPHTHALMIC LENSES | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2007-10-04 | — | — | US | disclosed |
| US-20070232835-A1 | THIOPHOSPHINE COMPOUNDS AND METHODS OF MAKING POLYMERIZABLE COMPOSITIONS CONTAINING THEM AND THEIR USE FOR MAKING OPHTHALMIC LENSES | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2007-10-04 | — | — | US | disclosed |
| US-7129321-B2 | Thiophosphine compounds and methods of making polymerizable compositions containing them and their use for making ophthalmic lenses | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2006-10-31 | — | — | US | disclosed |
| EP-1608704-A2 | THIOPHOSPHINE COMPOUNDS AND METHOD OF MAKING POLYMERISABLE COMPOSITIONS CONTAINING THEM AND THEIR USE FOR MAKING OPHTALMIC LENSES | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2005-12-28 | — | — | EP | disclosed |
| US-20050107579-A1 | Thiophosphine compounds and methods of making polymerizable compositions containing them and their use for making ophthalmic lenses | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2005-05-19 | — | — | US | disclosed |
| WO-2004085447-A2 | THIOPHOSPHINE COMPOUNDS AND METHOD OF MAKING POLYMERISABLE COMPOSITIONS CONTAINING THEM AND THEIR USE FOR MAKING OPHTALMIC LENSES | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2004-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232835-A1 | THIOPHOSPHINE COMPOUNDS AND METHODS OF MAKING POLYMERIZABLE COMPOSITIONS CONTAINING THEM AND THEIR USE FOR MAKING OPHTHALMIC LENSES | PHOSPHO1, TST, UACA | ESR1 4716/4885ESR2 4648/4885KMT2A 3598/4885 |
| US-20070232834-A1 | THIOPHOSPHINE COMPOUNDS AND METHODS OF MAKING POLYMERIZABLE COMPOSITIONS CONTAINING THEM AND THEIR USE FOR MAKING OPHTHALMIC LENSES | PHOSPHO1, TST, UACA | ESR1 4716/4885ESR2 4648/4885KMT2A 3598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.