Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 3/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.41 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4622870 | 0.94 | PSEN1 (0.38) | BCL2NR4A2NR4A1NR4A3PTGES | |
| SCHEMBL2247850 | 0.91 | PTGES (0.43) | BCL2NR4A2NR4A1NR4A3PTGES | |
| SCHEMBL2244683 | 0.91 | SPHK2 (0.43) | PTGESALOX5LTC4SSPHK2KMT2A | |
| SCHEMBL2249360 | 0.90 | BCL2 (0.43) | BCL2NR4A2NR4A1NR4A3PTGES | |
| SCHEMBL4374329 | 0.89 | PSEN1 (0.44) | BCL2NR4A2PTGESALOX5KMT2A | |
| SCHEMBL2250531 | 0.86 | HSD17B2 (0.43) | PTGESALOX5LTC4SPKMMAOB | |
| SCHEMBL2249759 | 0.85 | RXRA (0.47) | PTGESALOX5LTC4SRXRARXRB | |
| SCHEMBL2243828 | 0.84 | EPOR (0.38) | BCL2NR4A2NR4A1NR4A3PTGES | |
| SCHEMBL2245867 | 0.83 | MMP2 (0.40) | PTGESALOX5 | |
| SCHEMBL2244933 | 0.83 | HSD17B2 (0.51) | PTGESALOX5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902014-A2 | GLUTAMATE AGGRECANASE INHIBITORS | Wyeth (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007008994-A2 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2007-01-18 | — | — | WO | disclosed |