Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 5/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4624316 | 1.00 | MTNR1A (0.50) | MTNR1AMTNR1BAKR1C3CNR1CNR2 | |
| SCHEMBL11902132 | 0.86 | RIPK1 (0.46) | MTNR1AMTNR1BAKR1C3CYP2C9 | |
| SCHEMBL491755 | 0.81 | AKR1C3 (0.47) | MTNR1AMTNR1BAKR1C3CYP2C9CES2 | |
| SCHEMBL9574176 | 0.77 | MTNR1A (0.41) | MTNR1AMTNR1BCNR1CNR2EPHX2 | |
| SCHEMBL15240402 | 0.76 | AKR1C3 (0.46) | MTNR1AMTNR1BAKR1C3CYP2C9 | |
| SCHEMBL234526 | 0.76 | MTNR1A (0.41) | MTNR1AMTNR1BAKR1C3CYP2C9APEX1 | |
| SCHEMBL29091274 | 0.76 | MTNR1A (0.44) | MTNR1AMTNR1BCNR1CNR2EPHX2 | |
| SCHEMBL28348801 | 0.75 | MTNR1A (0.46) | MTNR1AMTNR1BCNR1CNR2EPHX2 | |
| SCHEMBL8855503 | 0.74 | AKR1C3 (0.45) | AKR1C3CNR2CYP2C9 | |
| SCHEMBL197322 | 0.74 | GRIK1 (0.53) | AKR1C3CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444239-B1 | HIGH REFRACTIVE INDEX AROMATIC-BASED SILYL MONOMERS | BAUSCH & LOMB (US) | 2008-12-24 | — | — | EP | claimed |
| EP-1448571-B1 | HIGH REFRACTIVE INDEX AROMATIC-BASED SILOXANE MONOFUNCTIONAL MACROMONOMERS | BAUSCH & LOMB (US) | 2008-05-21 | — | — | EP | claimed |