SCHEMBL8855503

SCHEMBL8855503

CC(=CCCC(O)C=Cc1ccccc1)C(=O)O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 1/20 0.45
GLA P06280 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
CYP1A2 P05177 2/20 0.41
CNR2 P34972 1/20 0.38
CYP3A4 P08684 1/20 0.38
ALDH1A1 P00352 2/20 0.37
HAO1 Q9UJM8 1/20 0.37
PAM P19021 1/20 0.37
HDAC3 O15379 1/20 0.36
TNKS O95271 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC1 Q13547 1/20 0.36
HCAR2 Q8TDS4 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC10 Q969S8 1/20 0.36
HDAC11 Q96DB2 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
TNKS2 Q9H2K2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5189597 0.85 AKR1C3 (0.47) AKR1C3GLATDP1CYP1A2CNR2
Pyruvate SCHEMBL28628122 0.77 ACHE (0.49) GLATDP1CYP1A2HDAC3HDAC4
SCHEMBL3655195 0.76 AKR1C3 (0.52) AKR1C3GLATDP1CYP1A2ALDH1A1
SCHEMBL5574588 0.76 ALDH1A1 (0.58) AKR1C3GLATDP1CYP1A2ALDH1A1
SCHEMBL2206789 0.76 ALDH1A1 (0.58) AKR1C3GLATDP1CYP1A2ALDH1A1
SCHEMBL5574579 0.76 ALDH1A1 (0.58) AKR1C3GLATDP1CYP1A2ALDH1A1
SCHEMBL11902132 0.75 RIPK1 (0.46) AKR1C3LMNACYP2C9SMN1; SMN2PPARG
SCHEMBL4624323 0.74 MTNR1A (0.50) AKR1C3CNR2CYP2C9
SCHEMBL4624316 0.74 MTNR1A (0.50) AKR1C3CNR2CYP2C9
SCHEMBL6897130 0.74 MEN1 (0.42) GLATDP1CYP1A2CNR2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5693710-A PAINT COMPOSITION CONTAINING TWO-COMPONENT POLYURETHANE METALLIC BASE AND SOLID BASE COATS AND BLEND OF POLYOLEFIN AND FIRST AND SECOND RUBBERS HONDA GIKEN KOGYO KABUSHIKI KAISHA (JP) 1997-12-02 US disclosed
US-5498671-A ADHESION FOR COATINGS D & S PLASTIC INTERNATIONAL (US) 1996-03-12 US disclosed