⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6056854 | 0.77 | — | — | |
| SCHEMBL12998775 | 0.74 | KDM4E (0.52) | — | |
| SCHEMBL11256791 | 0.74 | — | — | |
| SCHEMBL12724708 | 0.74 | AURKA (0.34) | — | |
| SCHEMBL14606030 | 0.73 | — | — | |
| SCHEMBL1782191 | 0.73 | — | — | |
| SCHEMBL31205727 | 0.73 | — | — | |
| SCHEMBL11847450 | 0.72 | KDR (0.36) | — | |
| SCHEMBL5632484 | 0.71 | ROCK1 (0.38) | — | |
| SCHEMBL4884433 | 0.71 | AURKA (0.65) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1921143-A2 | Mutants of desoxycytidine kinase having extended enzymatic activity | INSTITUT PASTEUR (FR) | 2008-05-14 | — | — | EP | disclosed |
| EP-1383890-B1 | MUTANTS OF DESOXYCYTIDINE KINASE HAVING EXTENDED ENZYMATIC ACTIVITY | PASTEUR INSTITUT (FR) | 2008-05-14 | — | — | EP | disclosed |
| EP-1383890-A2 | MUTANTS OF DESOXYCYTIDINE KINASE HAVING EXTENDED ENZYMATIC ACTIVITY | INSTITUT PASTEUR (FR) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002083892-A2 | MUTANTS OF DESOXYCYTIDINE KINASE HAVING EXTENDED ENZYMATIC ACTIVITY | INSTITUT PASTEUR (FR) | 2002-10-24 | — | — | WO | disclosed |