⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31205727 | 1.00 | — | — | |
| SCHEMBL23887607 | 0.81 | SYK (0.42) | — | |
| SCHEMBL27764814 | 0.78 | GABRA1 (0.38) | — | |
| SCHEMBL445950 | 0.77 | — | — | |
| SCHEMBL29909710 | 0.77 | — | — | |
| Salicyladehyde SCHEMBL29001184 | 0.77 | TRIM24 (0.49) | — | |
| SCHEMBL11256791 | 0.74 | — | — | |
| SCHEMBL12998775 | 0.74 | KDM4E (0.52) | — | |
| SCHEMBL22896965 | 0.74 | GRM5 (0.35) | — | |
| SCHEMBL17601584 | 0.74 | LMNA (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 131 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114106020-B | Pyrimidine Schiff base o-phenanthroline-copper-based high anticancer active complex and preparation method thereof | 广东石油化工学院 | 2023-05-12 | — | — | CN | claimed |
| CN-113105459-B | Triazolopyrimidine derivative and preparation method and application thereof | 五邑大学 | 2022-05-03 | — | — | CN | claimed |
| CN-114106020-A | Pyrimidine Schiff base and phenanthroline-copper-based high-anticancer-activity complex and preparation method thereof | 广东石油化工学院 | 2022-03-01 | — | — | CN | claimed |
| CN-113105459-A | Triazolopyrimidine derivative and preparation method and application thereof | 五邑大学 | 2021-07-13 | — | — | CN | claimed |
| US-20260062391-A1 | HYDRAZIDE CONTAINING NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | KARYOPHARM THERAPEUTICS INC (US) | 2026-03-05 | — | — | US | disclosed |
| US-12291508-B2 | Hydrazide containing nuclear transport modulators and uses thereof | Karyopharm Therapeutics Inc. (US) | 2025-05-06 | — | — | US | disclosed |
| US-20240279188-A1 | HYDRAZIDE CONTAINING NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | WILMINGTON SAVINGS FUND SOCIETY, FSB, AS AGENT | 2024-08-22 | — | — | US | disclosed |
| CN-117229268-A | Hydrazide-containing nuclear transport modulators and uses thereof | 卡尔约药物治疗公司 | 2023-12-15 | — | — | CN | disclosed |
| US-11787771-B2 | Hydrazide containing nuclear transport modulators and uses thereof | Karyopharm Therapeutics Inc. (US) | 2023-10-17 | — | — | US | disclosed |
| US-11787771-B2 | Hydrazide containing nuclear transport modulators and uses thereof | Karyopharm Therapeutics Inc. (US) | 2023-10-17 | — | — | US | disclosed |
| US-11787771-B2 | Hydrazide containing nuclear transport modulators and uses thereof | Karyopharm Therapeutics Inc. (US) | 2023-10-17 | — | — | US | disclosed |
| CN-110372673-B | Hydrazide-containing nuclear transport modulators and uses thereof | 卡尔约药物治疗公司 | 2023-10-03 | — | — | CN | disclosed |
| US-20080014189-A1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED | 2008-01-17 | — | — | US | disclosed |
| US-7279469-B2 | Diaminotriazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-09 | — | — | US | disclosed |
| US-7279469-B2 | Diaminotriazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-09 | — | — | US | disclosed |
| US-7279469-B2 | Diaminotriazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-09 | — | — | US | disclosed |
| CN-1738615-A | Diaminotriazoles as inhibitors of protein kinases | VERTEX PHARMA (US) | 2006-02-22 | — | — | CN | disclosed |
| EP-1562589-A2 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | Vertex Pharmaceuticals Incorporated (US) | 2005-08-17 | — | — | EP | disclosed |
| US-20040214817-A1 | Diaminotriazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2004-10-28 | — | — | US | disclosed |
| WO-2004046120-A2 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-06-03 | — | — | WO | disclosed |