⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12724708 | 0.78 | AURKA (0.34) | — | |
| SCHEMBL4625173 | 0.77 | — | — | |
| SCHEMBL2751436 | 0.74 | — | — | |
| SCHEMBL10065608 | 0.74 | CYP1A2 (0.47) | — | |
| SCHEMBL30803768 | 0.74 | — | — | |
| SCHEMBL29909710 | 0.73 | — | — | |
| SCHEMBL28119404 | 0.73 | — | — | |
| SCHEMBL2745397 | 0.73 | — | — | |
| SCHEMBL445950 | 0.73 | — | — | |
| SCHEMBL2745354 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2963033-A1 | BENZIMIDAZOLE-4-CARBOXAMIDE DERIVATES, THEIR PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS AND THEIR USES | Shanghai Jiao Tong University (CN) | 2016-01-06 | — | — | EP | disclosed |
| US-8871946-B2 | Benzimidazole-4-carboxamide derivatives, their preparation methods, pharmaceutical compositions and their uses | ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY (CN) | 2014-10-28 | — | — | US | disclosed |
| US-8871946-B2 | Benzimidazole-4-carboxamide derivatives, their preparation methods, pharmaceutical compositions and their uses | ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY (CN) | 2014-10-28 | — | — | US | disclosed |
| EP-2386553-A1 | BENZIMIDAZOLE-4-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS AND THEIR USES | Shanghai Jiao Tong University (CN) | 2011-11-16 | — | — | EP | disclosed |
| US-20110269766-A1 | Benzimidazole-4-Carboxamide Derivatives, Their Preparation Methods, Pharmaceutical Compositions And Their Uses | ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY (CN) | 2011-11-03 | — | — | US | disclosed |
| US-20110269766-A1 | Benzimidazole-4-Carboxamide Derivatives, Their Preparation Methods, Pharmaceutical Compositions And Their Uses | ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY (CN) | 2011-11-03 | — | — | US | disclosed |
| WO-2006110106-A1 | STABILISER COMPOSITION FOR CHLORINE-CONTAINING POLYMERS | SUN ACE KAKOK (PTE.) LTD. (SG) | 2006-10-19 | — | — | WO | disclosed |