Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4628806 | 0.88 | PDE4B (0.57) | PDE4BMTNR1BCSF1RGAAALDH1A1 | |
| SCHEMBL4627538 | 0.88 | PDE4B (0.54) | PDE4BMTNR1BCSF1RJAK2JAK3 | |
| SCHEMBL4627674 | 0.87 | PDE4B (0.56) | PDE4BALOX5APFEN1MTNR1BCSF1R | |
| SCHEMBL4625977 | 0.85 | PDE4B (0.71) | PDE4BCSF1RKCNH2 | |
| Hydrochloric Acid SCHEMBL4628811 | 0.85 | PDE4B (0.70) | PDE4BCSF1RKCNH2 | |
| SCHEMBL4949173 | 0.83 | PDE4B (0.69) | PDE4BMTNR1BCSF1RJAK2JAK3 | |
| SCHEMBL4627082 | 0.82 | PDE4B (0.51) | PDE4BMTNR1BCSF1RKCNH2ALDH1A1 | |
| SCHEMBL4628322 | 0.80 | PDE4B (0.57) | PDE4BMTNR1BCSF1RKCNH2GAA | |
| SCHEMBL4626847 | 0.80 | PDE4B (0.56) | PDE4BMTNR1BCSF1RKCNH2 | |
| SCHEMBL5404792 | 0.79 | PDE4B (0.51) | PDE4BMTNR1BCSF1RPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673086-B1 | 4-AMINOQUINOLINE-3-CARBOXAMIDE DERIVATIVES AS PDE4 INHIBITORS | GLAXO GROUP LTD (GB) | 2008-01-23 | — | — | EP | claimed |