Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CSF1R | P07333 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4625986 | 0.92 | PDE4B (0.55) | PDE4BCSF1RMTNR1B | |
| SCHEMBL4628806 | 0.90 | PDE4B (0.57) | PDE4BGAAMAPTCSF1RATM | |
| SCHEMBL4949101 | 0.88 | PDE4B (0.68) | PDE4BCSF1RMTNR1B | |
| SCHEMBL4627105 | 0.88 | PDE4B (0.61) | PDE4BGAAMAPTCYP3A4CYP2C9 | |
| SCHEMBL4949711 | 0.85 | PDE4B (0.64) | PDE4BGAACSF1RSMN1; SMN2MTNR1B | |
| SCHEMBL4952737 | 0.83 | PDE4B (0.61) | PDE4BCSF1R | |
| SCHEMBL4628792 | 0.83 | PDE4B (0.57) | PDE4BGAAMAPTCSF1RKCNH2 | |
| SCHEMBL4946724 | 0.83 | PDE4B (0.56) | PDE4BCYP3A4CYP2C9CSF1RKCNH2 | |
| SCHEMBL4627674 | 0.82 | PDE4B (0.56) | PDE4BCSF1RMTNR1BMAPK1 | |
| SCHEMBL4627084 | 0.82 | PDE4B (0.76) | PDE4BCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673086-B1 | 4-AMINOQUINOLINE-3-CARBOXAMIDE DERIVATIVES AS PDE4 INHIBITORS | GLAXO GROUP LTD (GB) | 2008-01-23 | — | — | EP | claimed |