Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.32 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4628806 | 0.87 | PDE4B (0.57) | PDE4BKDM4EALDH1A1CSF1RMTNR1B | |
| SCHEMBL4627674 | 0.86 | PDE4B (0.56) | PDE4BALDH1A1CSF1RMTNR1BHTR4 | |
| SCHEMBL4627076 | 0.86 | PDE4B (0.67) | PDE4BKDM4ECSF1RKCNH2SCN5A | |
| SCHEMBL4627538 | 0.84 | PDE4B (0.54) | PDE4BKDM4EALDH1A1CSF1RPKM | |
| SCHEMBL4625979 | 0.82 | PDE4B (0.54) | PDE4BALDH1A1CSF1RKCNH2MTNR1B | |
| SCHEMBL4949173 | 0.80 | PDE4B (0.69) | PDE4BCSF1RMTNR1B | |
| SCHEMBL4948178 | 0.78 | PDE4B (0.61) | PDE4BMTNR1B | |
| SCHEMBL4628322 | 0.78 | PDE4B (0.57) | PDE4BCSF1RCYP3A4KCNH2MTNR1B | |
| SCHEMBL4625986 | 0.77 | PDE4B (0.55) | PDE4BCSF1RMTNR1BHTR4 | |
| SCHEMBL4626847 | 0.76 | PDE4B (0.56) | PDE4BCSF1RKCNH2MTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673086-B1 | 4-AMINOQUINOLINE-3-CARBOXAMIDE DERIVATIVES AS PDE4 INHIBITORS | GLAXO GROUP LTD (GB) | 2008-01-23 | — | — | EP | claimed |