Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.39 |
| ▸ | GSTM2 | P28161 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GALR2 | O43603 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SLC5A1 | P13866 | 3/20 | 0.38 |
| ▸ | SLC5A2 | P31639 | 3/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL406775 | 0.86 | MAPT (0.43) | ALDH1A1SMN1; SMN2GSTP1GSTM2MITF | |
| SCHEMBL405091 | 0.84 | KCNMA1 (0.46) | ALDH1A1SMN1; SMN2GSTP1GSTM2MITF | |
| SCHEMBL406805 | 0.84 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2GSTP1GSTM2MITF | |
| SCHEMBL12246127 | 0.83 | PPARD (0.42) | ALDH1A1SMN1; SMN2GSTP1GSTM2MITF | |
| SCHEMBL17499989 | 0.81 | PTGS1 (0.47) | ALDH1A1SMN1; SMN2GSTP1GSTM2MITF | |
| SCHEMBL406826 | 0.78 | KCNMA1 (0.48) | ALDH1A1SMN1; SMN2MITFLMNAPOLB | |
| SCHEMBL406405 | 0.78 | SMN1; SMN2 (0.41) | ALDH1A1SMN1; SMN2GSTP1GSTM2MITF | |
| SCHEMBL26922972 | 0.75 | PTGS1 (0.46) | ALDH1A1SMN1; SMN2GSTP1GSTM2MITF | |
| SCHEMBL28420574 | 0.69 | GABRA1 (0.40) | LMNAHSP90AA1KMT2ANPC1RAB9A | |
| SCHEMBL462862 | 0.69 | MAPT (0.42) | ALDH1A1SMN1; SMN2MITFLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065187-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | ALCON RESEARCH, LTD (US) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065187-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | HRH4, HRH3, HRH2 | ALDH1A1 1909/4885SMN1; SMN2 4774/4885GSTP1 4652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.