Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | NNMT | P40261 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7574764 | 0.75 | AR (0.32) | ARNR3C1PGRNR3C2MAOA | |
| SCHEMBL22019330 | 0.67 | HTR2C (0.40) | ARNR3C1PGRNR3C2KDM4E | |
| SCHEMBL21317798 | 0.65 | HTR2A (0.39) | ARNR3C1PGRNR3C2KDM4E | |
| SCHEMBL13894801 | 0.65 | HTR2C (0.41) | ARNR3C1PGRNR3C2MAOA | |
| SCHEMBL28818061 | 0.63 | MAOA (0.41) | MAOADRD2KDM4ECYP2C9TSHR | |
| SCHEMBL14475657 | 0.63 | KIF11 (0.40) | ARNR3C1PGRNR3C2KDM4E | |
| SCHEMBL13831889 | 0.63 | KIF11 (0.40) | ARNR3C1PGRNR3C2DRD2 | |
| SCHEMBL18324164 | 0.62 | HTR5A (0.41) | KDM4E | |
| SCHEMBL7571638 | 0.62 | HTR5A (0.41) | KDM4E | |
| SCHEMBL18271939 | 0.62 | HTR5A (0.41) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1234569-B1 | COMPOSITIONS FOR DYEING KERATIN FIBRES | LION CORP (JP) | 2008-07-02 | — | — | EP | disclosed |
| US-6958080-B2 | Compositions for dyeing keratinous fiber | LION CORPORATION (JP) | 2005-10-25 | — | — | US | disclosed |
| EP-1234569-A1 | COMPOSITIONS FOR DYEING HORNY FIBERS | Lion Corporation (JP) | 2002-08-28 | — | — | EP | disclosed |
| EP-1142562-A1 | HAIR DYE COMPOSITIONS | Lion Corporation (JP) | 2001-10-10 | — | — | EP | disclosed |
| EP-1142561-A1 | HAIR DYE COMPOSITIONS | Lion Corporation (JP) | 2001-10-10 | — | — | EP | disclosed |