Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4628792 | 0.89 | PDE4B (0.57) | SYKCSF1RPDE4BKCNH2 | |
| SCHEMBL4627627 | 0.87 | PDE4B (0.56) | SYKCSF1RPDE4B | |
| SCHEMBL4627626 | 0.85 | PDE4B (0.59) | CSF1RPDE4B | |
| SCHEMBL4625986 | 0.82 | PDE4B (0.55) | SYKCSF1RPDE4B | |
| SCHEMBL4627712 | 0.82 | PDE4B (0.54) | CSF1RPDE4B | |
| SCHEMBL4627091 | 0.82 | PDE4B (0.54) | CSF1RPDE4B | |
| SCHEMBL4626932 | 0.80 | PDE4B (0.59) | SYKCSF1RPDE4BPDE4APDE4C | |
| SCHEMBL4627414 | 0.78 | PDE4B (0.57) | CSF1RPDE4B | |
| SCHEMBL4627527 | 0.76 | PDE4B (0.62) | CSF1RPDE4B | |
| SCHEMBL4951411 | 0.76 | CSF1R (0.58) | SYKCSF1RPDE4BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673086-B1 | 4-AMINOQUINOLINE-3-CARBOXAMIDE DERIVATIVES AS PDE4 INHIBITORS | GLAXO GROUP LTD (GB) | 2008-01-23 | — | — | EP | claimed |