Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.57 |
| ▸ | CSF1R | P07333 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4627712 | 0.93 | PDE4B (0.54) | PDE4BCSF1RMEN1LMNAKMT2A | |
| SCHEMBL4627091 | 0.93 | PDE4B (0.54) | PDE4BCSF1RMAPTGAANR1H4 | |
| SCHEMBL4626932 | 0.90 | PDE4B (0.59) | PDE4BCSF1RMAPTGAASYK | |
| SCHEMBL4627633 | 0.89 | SYK (0.49) | PDE4BCSF1RSYKKCNH2 | |
| SCHEMBL4627527 | 0.87 | PDE4B (0.62) | PDE4BCSF1RL3MBTL1MAPTGAA | |
| SCHEMBL4627471 | 0.85 | PDE4B (0.47) | PDE4BCSF1RL3MBTL1MEN1LMNA | |
| SCHEMBL4627716 | 0.85 | PDE4B (0.60) | PDE4BCSF1RMAPTGAAKCNH2 | |
| SCHEMBL4628322 | 0.83 | PDE4B (0.57) | PDE4BCSF1RLMNAMAPTGAA | |
| SCHEMBL4627505 | 0.79 | PDE4B (0.60) | PDE4BCSF1RL3MBTL1MEN1LMNA | |
| SCHEMBL4626888 | 0.79 | PDE4B (0.60) | PDE4BCSF1RLMNAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673086-B1 | 4-AMINOQUINOLINE-3-CARBOXAMIDE DERIVATIVES AS PDE4 INHIBITORS | GLAXO GROUP LTD (GB) | 2008-01-23 | — | — | EP | claimed |