Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 4/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MC5R | P33032 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4627673 | 0.77 | ADRA2A (0.39) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL8882832 | 0.70 | HTR2A (0.60) | HTR2AHTR2CHTR2BCASRMAPK1 | |
| SCHEMBL2998678 | 0.63 | ALDH1A1 (0.60) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL1551477 | 0.63 | ADRA2A (0.52) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL2217426 | 0.63 | CASR (0.50) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| Hydrochloric Acid SCHEMBL9736744 | 0.62 | ADRA2A (0.54) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL27907152 | 0.62 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL10449589 | 0.62 | HTR2A (0.51) | HTR2AHTR2CHTR2BCASRMAPK1 | |
| SCHEMBL7915037 | 0.61 | MAPK1 (0.65) | HTR2AHTR2CHTR2BMAPK1MC5R | |
| SCHEMBL31509450 | 0.61 | MAPK1 (0.65) | HTR2AHTR2CHTR2BMAPK1MC5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981880-A2 | USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | claimed |
| WO-2007085556-A2 | USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | claimed |