Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.60 |
| ▸ | CSF1R | P07333 | 11/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4627626 | 0.90 | PDE4B (0.59) | PDE4BCSF1R | |
| SCHEMBL4627499 | 0.88 | PDE4B (0.74) | PDE4BCSF1RGAAMAPTALDH1A1 | |
| SCHEMBL4627712 | 0.86 | PDE4B (0.54) | PDE4BCSF1RGAAMAPTALDH1A1 | |
| SCHEMBL4628792 | 0.85 | PDE4B (0.57) | PDE4BCSF1RGAAMAPTKCNH2 | |
| SCHEMBL4627091 | 0.84 | PDE4B (0.54) | PDE4BCSF1RGAAMAPT | |
| SCHEMBL4951004 | 0.82 | PDE4B (0.58) | PDE4BCSF1R | |
| SCHEMBL4952559 | 0.82 | PDE4B (0.67) | PDE4BCSF1R | |
| SCHEMBL4627471 | 0.81 | PDE4B (0.47) | PDE4BCSF1RGAAMAPT | |
| SCHEMBL4627150 | 0.81 | PDE4B (0.61) | PDE4BCSF1R | |
| SCHEMBL12115499 | 0.81 | PDE4B (0.78) | PDE4BCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673086-B1 | 4-AMINOQUINOLINE-3-CARBOXAMIDE DERIVATIVES AS PDE4 INHIBITORS | GLAXO GROUP LTD (GB) | 2008-01-23 | — | — | EP | claimed |