Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4626798 | 0.88 | CYP1A2 (0.50) | PYGLSMN1; SMN2ALDH1A1HPGDKDM4E | |
| SCHEMBL4627658 | 0.84 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1HPGDKDM4ECYP1A2 | |
| SCHEMBL4628276 | 0.81 | TAS1R3 (0.52) | SMN1; SMN2ALDH1A1HPGDHDAC8HDAC1 | |
| SCHEMBL4626818 | 0.79 | RAB9A (0.51) | PYGLSMN1; SMN2CYP1A2MAPTMEN1 | |
| SCHEMBL1554111 | 0.75 | HDAC1 (0.58) | ALDH1A1HPGDHDAC8HDAC1HDAC6 | |
| SCHEMBL4628354 | 0.75 | HDAC8 (0.60) | PYGLSMN1; SMN2ALDH1A1HDAC8HDAC1 | |
| SCHEMBL4628357 | 0.75 | HDAC8 (0.60) | PYGLSMN1; SMN2ALDH1A1HDAC8HDAC1 | |
| SCHEMBL13425100 | 0.75 | MAPT (0.58) | ALDH1A1HDAC8HDAC1HDAC6KDM4E | |
| SCHEMBL1554272 | 0.75 | MAPT (0.54) | ALDH1A1HDAC8HDAC1HDAC6KDM4E | |
| Hydrochloric Acid SCHEMBL1579963 | 0.74 | HDAC1 (0.56) | ALDH1A1HPGDHDAC8HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590333-A4 | GLYCOGEN SYNTHASE KINASE 3BETA INHIBITOR, COMPOSITION AND PROCESS FOR THE PREPARATION THEREOF | CRYSTALGENOMICS INC (KR) | 2008-04-30 | — | — | EP | disclosed |
| US-7179832-B2 | Glycogen synthase kinase 3β inhibitor, composition and process for the preparation thereof | CRYSTALGENOMICS, INC. (KR) | 2007-02-20 | — | — | US | disclosed |
| US-20060079521-A1 | Glycogen synthase kinase 3beta inhibitor, composition and process for the preparation thereof | CRYSTALGENOMICS, INC. (KR) | 2006-04-13 | — | — | US | disclosed |
| EP-1590333-A1 | GLYCOGEN SYNTHASE KINASE 3BETA INHIBITOR, COMPOSITION AND PROCESS FOR THE PREPARATION THEREOF | Crystalgenomics, Inc. (KR) | 2005-11-02 | — | — | EP | disclosed |
| WO-2004065370-A1 | GLYCOGEN SYNTHASE KINASE 3BETA INHIBITOR, COMPOSITION AND PROCESS FOR THE PREPARATION THEREOF | CRYSTALGENOMICS, INC. (KR) | 2004-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079521-A1 | Glycogen synthase kinase 3beta inhibitor, composition and process for the preparation thereof | GSK3B, GSK3A, GYS2 | PYGL 7/4885SMN1; SMN2 2993/4885ALDH1A1 3930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.