Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 3/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 3/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4657955 | 0.90 | ICMT (0.46) | ICMTF2PRSS1PLA2G2ACYSLTR2 | |
| SCHEMBL4626809 | 0.81 | ICMT (0.47) | ICMTF2PRSS1PLA2G2ACYSLTR2 | |
| SCHEMBL5900052 | 0.80 | MTNR1A (0.49) | ICMTMTNR1AMTNR1BF2PRSS1 | |
| SCHEMBL4627926 | 0.80 | PLA2G2A (0.54) | ICMTMTNR1AMTNR1BF2PRSS1 | |
| SCHEMBL4657400 | 0.78 | F10 (0.44) | ICMTF2PRSS1CYSLTR2CYSLTR1 | |
| SCHEMBL4626941 | 0.76 | PLA2G2A (0.55) | ICMTMTNR1AMTNR1BF2PRSS1 | |
| SCHEMBL4656243 | 0.76 | ICMT (0.47) | ICMTF2PRSS1PLA2G2ACYSLTR2 | |
| SCHEMBL5899949 | 0.75 | ICMT (0.42) | ICMTF2PRSS1PLA2G2ACYSLTR2 | |
| SCHEMBL4655418 | 0.74 | PLA2G2A (0.49) | ICMTMTNR1AMTNR1BF2PRSS1 | |
| SCHEMBL5899891 | 0.74 | PLA2G2A (0.52) | ICMTMTNR1AMTNR1BF2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633716-A4 | BIARYLMETHYL INDOLINES, INDOLES AND TETRAHYDROQUINOLINES, USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2008-03-26 | — | — | EP | claimed |
| EP-1633716-A2 | BIARYLMETHYL INDOLINES, INDOLES AND TETRAHYDROQUINOLINES, USEFUL AS SERINE PROTEASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2006-03-15 | — | — | EP | claimed |
| WO-2004094372-A2 | COMPOUNDS USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-11-04 | — | — | WO | claimed |