Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.56 |
| ▸ | CSF1R | P07333 | 5/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | GCK | P35557 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1275608 | 0.89 | PDE4B (0.59) | PDE4BCSF1RKCNH2CYP3A4CYP2C9 | |
| SCHEMBL4949429 | 0.89 | PDE4B (0.50) | PDE4BCYP3A4CYP2C9 | |
| SCHEMBL4949101 | 0.85 | PDE4B (0.68) | PDE4BCSF1RMTNR1B | |
| SCHEMBL4628322 | 0.83 | PDE4B (0.57) | PDE4BCSF1RKCNH2CYP3A4CYP2C9 | |
| SCHEMBL8312156 | 0.83 | PDE4B (0.57) | PDE4BCSF1RMTNR1B | |
| SCHEMBL4625986 | 0.83 | PDE4B (0.55) | PDE4BCSF1RMTNR1BSYK | |
| Hydrochloric Acid SCHEMBL4264207 | 0.82 | PDE4B (0.57) | PDE4BCSF1RMTNR1B | |
| SCHEMBL4949711 | 0.82 | PDE4B (0.64) | PDE4BCSF1RMTNR1B | |
| SCHEMBL8313135 | 0.81 | PDE4B (0.59) | PDE4BCSF1RKCNH2 | |
| SCHEMBL8308172 | 0.81 | PDE4B (0.57) | PDE4BCSF1RKCNH2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633748-B1 | QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-03-05 | — | — | EP | claimed |