Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4629511 | 0.85 | TAAR1 (0.40) | GABRA1GABRB2POLBKDM4EHSD17B10 | |
| SCHEMBL4628344 | 0.77 | GABRA1 (0.35) | GABRA1GABRB2POLBKDM4EHSD17B10 | |
| SCHEMBL7923371 | 0.76 | CALM1 (0.48) | POLBKDM4EALDH1A1HPGDTP53 | |
| SCHEMBL17622 | 0.75 | CXCR2 (0.42) | GABRA1GABRB2POLBKDM4EHSD17B10 | |
| SCHEMBL17279789 | 0.74 | SMN1; SMN2 (0.42) | GABRA1GABRB2POLBKDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL8588873 | 0.73 | CXCR2 (0.41) | GABRA1GABRB2POLBKDM4EHSD17B10 | |
| SCHEMBL82538 | 0.73 | TAAR1 (0.43) | GABRA1GABRB2POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL28856048 | 0.72 | CCR1 (0.43) | GABRA1GABRB2POLBKDM4EHSD17B10 | |
| SCHEMBL3844900 | 0.72 | GABRA1 (0.48) | GABRA1GABRB2POLBKDM4EHSD17B10 | |
| SCHEMBL9371816 | 0.72 | TAAR1 (0.51) | POLBKDM4ESMN1; SMN2ALDH1A1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981880-A2 | USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085556-A2 | USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | disclosed |