SCHEMBL4628344

SCHEMBL4628344

Cc1cc(C)c(C)c(Cc2c[nH]cn2)c1C.c1ccc(Cc2c[nH]cn2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 1/20 0.35
GABRB2 P47870 1/20 0.35
ALDH1A1 P00352 3/20 0.34
TAAR1 Q96RJ0 1/20 0.34
HTR2B P41595 1/20 0.34
POLB P06746 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.32
KDM4E B2RXH2 2/20 0.32
HTT P42858 1/20 0.32
HSD17B10 Q99714 1/20 0.32
TLR8 Q9NR97 1/20 0.32
RAB9A P51151 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
LMNA P02545 1/20 0.32
TSHR P16473 2/20 0.31
HTR2C P28335 1/20 0.31
HPGD P15428 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2102413 0.88
SCHEMBL4629510 0.85 TAAR1 (0.40) GABRA1GABRB2ALDH1A1TAAR1POLB
SCHEMBL649075 0.83 ALDH1A1 (0.46) ALDH1A1TAAR1HTR2BPOLBSMN1; SMN2
SCHEMBL10405991 0.79
SCHEMBL4628348 0.77 GABRA1 (0.40) GABRA1GABRB2ALDH1A1TAAR1HTR2B
SCHEMBL7923371 0.76 CALM1 (0.48) ALDH1A1POLBKDM4ELMNAHPGD
SCHEMBL2103783 0.75 TAAR1 (0.46) ALDH1A1TAAR1POLBHSD17B10LMNA
SCHEMBL6967970 0.74 ALDH1A1 (0.39) ALDH1A1TAAR1HTR2BSMN1; SMN2HSD17B10
SCHEMBL11045854 0.74 DAO (0.42) TAAR1HTR2BLMNAHTR2CHPGD
SCHEMBL6972732 0.73 NOTUM (0.39) GABRA1GABRB2ALDH1A1TAAR1HTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1981880-A2 USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS F.HOFFMANN-LA ROCHE AG (CH) 2008-10-22 EP disclosed
WO-2007085556-A2 USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS F. HOFFMANN-LA ROCHE AG (CH) 2007-08-02 WO disclosed