Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | BLM | P54132 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CES1 | P23141 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL416283 | 0.89 | MALT1 (0.51) | IDO1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL4657699 | 0.69 | S100A4 (0.67) | IDO1MEN1KMT2AMAPTKDM4E | |
| Alpha-Lapachone SCHEMBL102553 | 0.67 | IDO1 (1.00) | IDO1MEN1KMT2AMAPTKDM4E | |
| Alpha-Lapachone SCHEMBL29355317 | 0.67 | IDO1 (1.00) | IDO1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL12798036 | 0.64 | CES1 (0.54) | IDO1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL545308 | 0.63 | MEN1 (0.55) | IDO1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL29519720 | 0.63 | MEN1 (0.55) | IDO1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL28215631 | 0.63 | MEN1 (0.55) | IDO1MEN1KMT2AMAPTKDM4E | |
| Lapachone SCHEMBL107042 | 0.62 | MALT1 (1.00) | IDO1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL11580301 | 0.62 | CDC25B (0.61) | IDO1MEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567515-A4 | NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF | ARQULE INC (US) | 2008-04-23 | — | — | EP | disclosed |
| EP-1567515-A2 | NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF | ARQULE, INC. (US) | 2005-08-31 | — | — | EP | disclosed |
| US-20040266857-A1 | Novel lapachone compounds and methods of use thereof | HINES GLOBAL EDUCATION | 2004-12-30 | — | — | US | disclosed |
| WO-2004045557-A2 | NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF | ARQULE, INC. (US) | 2004-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266857-A1 | Novel lapachone compounds and methods of use thereof | XIAP, MKI67, PIN1 | IDO1 1021/4885MEN1 2813/4885KMT2A 3488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.