Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 9/20 | 1.00 |
| ▸ | MALT1 | Q9UDY8 | 9/20 | 0.79 |
| ▸ | LMNA | P02545 | 2/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.79 |
| ▸ | CES2 | O00748 | 1/20 | 0.79 |
| ▸ | GMNN | O75496 | 1/20 | 0.79 |
| ▸ | TDP2 | O95551 | 1/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.79 |
| ▸ | TP53 | P04637 | 1/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.79 |
| ▸ | GLA | P06280 | 1/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.79 |
| ▸ | MAPT | P10636 | 1/20 | 0.79 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.79 |
| ▸ | THRB | P10828 | 1/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.79 |
| ▸ | NQO1 | P15559 | 1/20 | 0.79 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alpha-Lapachone SCHEMBL29355317 | 1.00 | IDO1 (1.00) | IDO1MALT1LMNAKDM4EMEN1 | |
| Lapachone SCHEMBL29351050 | 0.89 | MALT1 (1.00) | IDO1MALT1LMNAKDM4EMEN1 | |
| Lapachone SCHEMBL107042 | 0.89 | MALT1 (1.00) | IDO1MALT1LMNAKDM4EMEN1 | |
| SCHEMBL18790870 | 0.83 | IDO1 (0.71) | IDO1MALT1LMNAKDM4EMEN1 | |
| SCHEMBL15034364 | 0.81 | MALT1 (0.76) | IDO1MALT1LMNAKDM4EMEN1 | |
| SCHEMBL8186444 | 0.81 | MALT1 (0.76) | IDO1MALT1LMNAKDM4EMEN1 | |
| SCHEMBL10916020 | 0.79 | MALT1 (0.72) | IDO1MALT1LMNAKDM4EMEN1 | |
| SCHEMBL10916022 | 0.79 | MALT1 (0.72) | IDO1MALT1LMNAKDM4EMEN1 | |
| SCHEMBL28836927 | 0.79 | IDO1 (0.64) | IDO1MALT1LMNAKDM4EMEN1 | |
| SCHEMBL104546 | 0.78 | IDO1 (0.63) | IDO1MALT1LMNAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114209676-B | Nanometer diagnosis and treatment material and application thereof | 浙江大学杭州国际科创中心 | 2023-06-13 | — | — | CN | disclosed |
| CN-114209676-A | Nano diagnosis and treatment material and application thereof | 浙江大学杭州国际科创中心 | 2022-03-22 | — | — | CN | disclosed |
| WO-2017070012-A1 | LAPACHONE DERIVATIVES CONTAINING TWO REDOX CENTERS AND METHODS OF USE THEREOF | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-04-27 | — | — | WO | disclosed |
| EP-2301520-B1 | Oxidative dye | HENKEL AG & CO KGAA (DE) | 2017-03-08 | — | — | EP | disclosed |
| EP-2137168-B1 | NOVEL IDO INHIBITORS AND METHODS OF USE THEREOF | LANKENAU INST MEDICAL RES (US) | 2016-09-14 | — | — | EP | disclosed |
| US-20130183388-A1 | Novel IDO Inhibitors and Methods of Use Thereof | LANKENAU INSTITUTE FOR MEDICAL RESEARCH (US) | 2013-07-18 | — | — | US | disclosed |
| US-20130183388-A1 | Novel IDO Inhibitors and Methods of Use Thereof | LANKENAU INSTITUTE FOR MEDICAL RESEARCH (US) | 2013-07-18 | — | — | US | disclosed |
| US-8389568-B2 | IDO inhibitors and methods of use thereof | LANKENAU INSTITUTE FOR MEDICAL RESEARCH (US) | 2013-03-05 | — | — | US | disclosed |
| US-8389568-B2 | IDO inhibitors and methods of use thereof | LANKENAU INSTITUTE FOR MEDICAL RESEARCH (US) | 2013-03-05 | — | — | US | disclosed |
| EP-2426212-A1 | Method for controlling NAD(P)/NAD(P)H ratio by oxidoreductase | Md Bioalpha Co., Ltd. (KR) | 2012-03-07 | — | — | EP | disclosed |
| US-20090215145-A1 | METHOD FOR CONTROLLING NAD(P)/NAD(P)H RATIO BY OXIDOREDUCTASE | MD BIOALPHA CO., LTD. (KR) | 2009-08-27 | — | — | US | disclosed |
| US-20090215145-A1 | METHOD FOR CONTROLLING NAD(P)/NAD(P)H RATIO BY OXIDOREDUCTASE | MD BIOALPHA CO., LTD. (KR) | 2009-08-27 | — | — | US | disclosed |
| WO-2009060017-A1 | HAIR TREATMENT AGENT COMPRISING TILIROSIDE AND VITAMIN B | HENKEL AG & CO. KGAA (DE) | 2009-05-14 | — | — | WO | disclosed |
| WO-2009033833-A2 | COLORING AGENT HAVING NATURAL DYES AND 1,3-DIHYDROXYACETONE | HENKEL AG & CO. KGAA (DE) | 2009-03-19 | — | — | WO | disclosed |
| WO-2008115804-A1 | NOVEL IDO INHIBITORS AND METHODS OF USE THEREOF | LANKENAU INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-09-25 | — | — | WO | disclosed |
| EP-1567515-A4 | NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF | ARQULE INC (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007094632-A1 | METHOD FOR CONTROLLING NAD(P)/NAD(P)H RATIO BY OXIDOREDUCTASE | MD BIOALPHA CO., LTD. (KR) | 2007-08-23 | — | — | WO | disclosed |
| EP-1567515-A2 | NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF | ARQULE, INC. (US) | 2005-08-31 | — | — | EP | disclosed |
| US-20040266857-A1 | Novel lapachone compounds and methods of use thereof | HINES GLOBAL EDUCATION | 2004-12-30 | — | — | US | disclosed |
| WO-2004045557-A2 | NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF | ARQULE, INC. (US) | 2004-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266857-A1 | Novel lapachone compounds and methods of use thereof | XIAP, MKI67, PIN1 | IDO1 1021/4885MALT1 598/4885LMNA 67/4885 |
| US-20130183388-A1 | Novel IDO Inhibitors and Methods of Use Thereof | IDO1, IDO2, INMT | IDO1 1/4885MALT1 1031/4885LMNA 4874/4885 |
| US-20090215145-A1 | METHOD FOR CONTROLLING NAD(P)/NAD(P)H RATIO BY OXIDOREDUCTASE | NQO1, NADK, ME2 | IDO1 1756/4885MALT1 4170/4885LMNA 1441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.