Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | RBP4 | P02753 | 4/20 | 0.45 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.39 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | MAP2 | P11137 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL612409 | 0.83 | AVPR1A (0.66) | MEN1KMT2ARBP4AVPR1A | |
| SCHEMBL12024594 | 0.72 | MEN1 (0.45) | MEN1KMT2ARBP4AVPR1AADAM17 | |
| SCHEMBL615187 | 0.72 | AVPR1A (0.55) | MEN1KMT2AAVPR1A | |
| SCHEMBL613085 | 0.72 | AVPR1A (0.70) | MEN1KMT2ARBP4AVPR1A | |
| SCHEMBL614601 | 0.71 | MEN1 (0.61) | MEN1KMT2ARBP4AVPR1A | |
| SCHEMBL614916 | 0.71 | AVPR1A (0.56) | MEN1KMT2AAVPR1A | |
| SCHEMBL7569555 | 0.70 | BRD4 (0.49) | MEN1KMT2A | |
| SCHEMBL4063136 | 0.70 | MEN1 (0.41) | MEN1KMT2ARBP4AVPR1APTGDR2 | |
| SCHEMBL6922546 | 0.69 | GPR119 (0.51) | MEN1KMT2A | |
| SCHEMBL28771298 | 0.69 | AVPR1A (0.42) | MEN1KMT2AAVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917255-A2 | INDOL-3-YL-CARBONYL-PIPERIDIN AND PIPERAZIN DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007014851-A2 | INDOL-3-YL-CARBONYL-PIPERIDIN AND PIPERAZIN DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-08 | — | — | WO | disclosed |