Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705782 | 0.86 | MEN1 (0.66) | BRD4MEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL6922546 | 0.84 | GPR119 (0.51) | MEN1KMT2AL3MBTL1ALDH1A1MAPT | |
| SCHEMBL4705226 | 0.80 | GAA (0.58) | BRD4MEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL12897091 | 0.80 | CHRM4 (0.65) | MEN1KMT2AL3MBTL1CHRM4 | |
| SCHEMBL8135156 | 0.79 | MEN1 (0.60) | MEN1KMT2AALDH1A1GAACHRM4 | |
| SCHEMBL14198379 | 0.76 | TSHR (0.63) | BRD4MEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL17755141 | 0.76 | ADRA2A (0.55) | MEN1KMT2AGPBAR1 | |
| SCHEMBL17620432 | 0.74 | SMN1; SMN2 (0.50) | MEN1KMT2AGPBAR1NPSR1 | |
| SCHEMBL12897298 | 0.74 | CHRM4 (0.58) | BRD4MEN1KMT2AL3MBTL1CHRM4 | |
| SCHEMBL7570603 | 0.74 | L3MBTL1 (0.56) | MEN1KMT2AL3MBTL1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0736009-B1 | N-OXIDES OF 4-ARYLPIPERAZINES AND 4-ARYLPIPERIDINES AS ANTIPSYCHOTIC DRUGS | ORTHO PHARMA CORP (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-0736009-A1 | N-OXIDES OF 4-ARYLPIPERAZINES AND 4-ARYLPIPERIDINES AS ANTIPSYCHOTIC DRUGS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1996-10-09 | — | — | EP | disclosed |
| WO-1995017385-A1 | N-OXIDES OF 4-ARYLPIPERAZINES AND 4-ARYLPIPERIDINES AS ANTIPSYCHOTIC DRUGS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1995-06-29 | — | — | WO | disclosed |
| EP-0562049-A1 | NOVEL 4-ARYLPIPERAZINES AND 4-ARYLPIPERIDINES | MCNEILAB, INC. (US) | 1993-09-29 | — | — | EP | disclosed |
| WO-1993004684-A1 | NOVEL 4-ARYLPIPERAZINES AND 4-ARYLPIPERIDINES | MCNEILAB, INC. (US) | 1993-03-18 | — | — | WO | disclosed |