Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL2779572 | 0.98 | RAB9A (0.53) | RAB9ANPC1PKMNAMPTKDM4E | |
| SCHEMBL1387772 | 0.81 | HSD17B10 (0.50) | RAB9ANPC1PKMKDM4ELMNA | |
| SCHEMBL15381295 | 0.79 | LMNA (0.57) | RAB9ANPC1PKMNAMPTKDM4E | |
| SCHEMBL8977657 | 0.79 | HTT (0.55) | RAB9ANPC1PKMKDM4ELMNA | |
| SCHEMBL7403710 | 0.78 | HSD17B10 (0.48) | RAB9ANPC1KMT2AMEN1TP53 | |
| Iodide SCHEMBL1286893 | 0.77 | HSD17B10 (0.46) | RAB9ANPC1KMT2AMEN1TP53 | |
| Hydrochloric Acid SCHEMBL9425234 | 0.77 | HSD17B10 (0.46) | RAB9ANPC1KMT2AMEN1TP53 | |
| SCHEMBL14538107 | 0.76 | NPC1 (0.51) | RAB9ANPC1PKMNAMPTKDM4E | |
| Pyraxinine SCHEMBL2456848 | 0.76 | RAB9A (0.55) | RAB9ANPC1PKMNAMPTKDM4E | |
| SCHEMBL4629194 | 0.76 | RAB9A (0.55) | RAB9ANPC1PKMNAMPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917244-A2 | HETARYL-SUBSTITUTED GUANIDINE COMPOUNDS AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5-RECEPTORS | Abbott GmbH & Co. KG (DE) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007022964-A2 | HETARYL-SUBSTITUTED GUANIDINE COMPOUNDS AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5-RECEPTORS | ABBOTT GMBH & CO. KG (DE) | 2007-03-01 | — | — | WO | disclosed |