Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 2/20 | 0.31 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2103689 | 0.72 | KDM4E (0.30) | KDM4ETAAR1 | |
| SCHEMBL14999441 | 0.69 | TAAR1 (0.39) | HSD17B10KDM4ETAAR1HSP90AA1 | |
| SCHEMBL2626856 | 0.68 | ADRA1D (0.42) | SMN1; SMN2TAAR1 | |
| SCHEMBL2103293 | 0.67 | PDE10A (0.31) | PDE10ADHFRKCNH2 | |
| SCHEMBL953878 | 0.67 | TAAR1 (0.62) | KDM4ESMN1; SMN2ALDH1A1ADRA1ATAAR1 | |
| SCHEMBL10044604 | 0.66 | CYP1A2 (0.46) | HSD17B10SMN1; SMN2ALDH1A1ADRA1ATAAR1 | |
| SCHEMBL2626855 | 0.65 | CYP19A1 (0.48) | TAAR1 | |
| SCHEMBL31429728 | 0.64 | CYP3A4 (0.38) | SMN1; SMN2ALDH1A1MTNR1AMTNR1B | |
| SCHEMBL2952706 | 0.64 | CA2 (0.43) | KDM4ESMN1; SMN2ADRA1ATAAR1HSP90AA1 | |
| SCHEMBL4630237 | 0.64 | TAAR1 (0.56) | TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981880-A2 | USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | claimed |
| WO-2007085556-A2 | USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | claimed |