Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.42 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PEPD | P12955 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1996992 | 0.87 | F2 (0.50) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL399197 | 0.80 | KIF11 (0.48) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL6880468 | 0.78 | F2 (0.43) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL447770 | 0.78 | PEPD (0.60) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL1438380 | 0.78 | MAPT (0.56) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL348736 | 0.76 | F2 (0.42) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL1186622 | 0.76 | NPC1 (0.61) | F2ALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4029597 | 0.76 | ALDH1A1 (0.61) | F2PRSS1PRSS2PRSS3ST14 | |
| Hydrochloric Acid SCHEMBL7249753 | 0.76 | MAPT (0.54) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL166139 | 0.76 | KIF11 (0.55) | CYP3A4CYP2C19MAPTKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534734-B1 | METHOD FOR THE SYNTHESIS AND SELECTIVE BIOCATALYTIC MODIFICATION OF PEPTIDES, PEPTIDE MIMETICS AND PROTEINS | ROCHE DIAGNOSTICS GMBH (DE) | 2008-05-07 | — | — | EP | claimed |
| US-20060149035-A1 | Method for the synthesis and selective biocatalytic modification of peptides, peptide mimetics and proteins | ROCHE DIAGNOSTICS GMBH (DE) | 2006-07-06 | — | — | US | claimed |
| EP-1534734-A1 | METHOD FOR THE SYNTHESIS AND SELECTIVE BIOCATALYTIC MODIFICATION OF PEPTIDES, PEPTIDE MIMETICS AND PROTEINS | BOEHRINGER MANNHEIM GMBH (DE) | 2005-06-01 | — | — | EP | claimed |
| WO-2004024751-A1 | METHOD FOR THE SYNTHESIS AND SELECTIVE BIOCATALYTIC MODIFICATION OF PEPTIDES, PEPTIDE MIMETICS AND PROTEINS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-03-25 | — | — | WO | claimed |
| EP-1534734-B1 | METHOD FOR THE SYNTHESIS AND SELECTIVE BIOCATALYTIC MODIFICATION OF PEPTIDES, PEPTIDE MIMETICS AND PROTEINS | ROCHE DIAGNOSTICS GMBH (DE) | 2008-05-07 | — | — | EP | disclosed |
| US-20060149035-A1 | Method for the synthesis and selective biocatalytic modification of peptides, peptide mimetics and proteins | ROCHE DIAGNOSTICS GMBH (DE) | 2006-07-06 | — | — | US | disclosed |
| EP-1534734-A1 | METHOD FOR THE SYNTHESIS AND SELECTIVE BIOCATALYTIC MODIFICATION OF PEPTIDES, PEPTIDE MIMETICS AND PROTEINS | BOEHRINGER MANNHEIM GMBH (DE) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004024751-A1 | METHOD FOR THE SYNTHESIS AND SELECTIVE BIOCATALYTIC MODIFICATION OF PEPTIDES, PEPTIDE MIMETICS AND PROTEINS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-03-25 | — | — | WO | disclosed |