Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 16/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | GABRE | P78334 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.35 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.35 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4630257 | 0.90 | GRM5 (0.82) | GRM5KCNH2FFAR1GABRPGABRD | |
| SCHEMBL2173276 | 0.90 | GRM5 (0.82) | GRM5KCNH2FFAR1NR3C1NR3C2 | |
| SCHEMBL4630909 | 0.90 | GRM5 (0.81) | GRM5KCNH2FFAR1GABRPGABRD | |
| SCHEMBL4630732 | 0.88 | GRM5 (0.78) | GRM5KCNH2FFAR1GABRPGABRD | |
| SCHEMBL29378035 | 0.88 | GRM5 (0.78) | GRM5KCNH2FFAR1NR3C1ADRB3 | |
| SCHEMBL2172336 | 0.88 | GRM5 (0.78) | GRM5KCNH2FFAR1NR3C1ADRB3 | |
| SCHEMBL4630585 | 0.88 | GRM5 (0.78) | GRM5KCNH2ADRB3TSPOTMEM97 | |
| SCHEMBL4630581 | 0.88 | GRM5 (0.78) | GRM5KCNH2FFAR1GABRPGABRD | |
| SCHEMBL4630692 | 0.87 | GRM5 (0.77) | GRM5KCNH2FFAR1GABRPGABRD | |
| SCHEMBL2173658 | 0.87 | GRM5 (0.77) | GRM5KCNH2ADRB3TSPOTMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210317058-A1 | DEGRADABLE POLYMERS AND MONOMERS THEREFOR | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2021-10-14 | — | — | US | claimed |
| EP-1606277-B8 | IMIDAZOL-4-YL-ETHYNYL-PYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-10-15 | — | — | EP | claimed |
| EP-1606277-B1 | IMIDAZOL-4-YL-ETHYNYL-PYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-05-14 | — | — | EP | claimed |
| US-7153874-B2 | Imidazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-12-26 | — | — | US | claimed |
| EP-1606277-A1 | IMIDAZOL-4-YL-ETHYNYL-PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-21 | — | — | EP | claimed |
| US-20040229917-A1 | Imidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-18 | — | — | US | claimed |
| WO-2004080998-A1 | IMIDAZOL-4-YL-ETHYNYL-PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-23 | — | — | WO | claimed |
| US-20210317058-A1 | DEGRADABLE POLYMERS AND MONOMERS THEREFOR | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2021-10-14 | — | — | US | disclosed |
| EP-1606277-B8 | IMIDAZOL-4-YL-ETHYNYL-PYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-10-15 | — | — | EP | disclosed |
| EP-1920029-A1 | PROCESS FOR CONVERTING DIFFICULTLY CONVERTIBLE OXYGENATES TO GASOLINE | Haldor Topsoe A/S (DK) | 2008-05-14 | — | — | EP | disclosed |
| EP-1606277-B1 | IMIDAZOL-4-YL-ETHYNYL-PYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007020068-A1 | PROCESS FOR CONVERTING DIFFICULTLY CONVERTIBLE OXYGENATES TO GASOLINE | HALDOR TOPSØE A/S (DK) | 2007-02-22 | — | — | WO | disclosed |
| US-7153874-B2 | Imidazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-12-26 | — | — | US | disclosed |
| EP-1606277-A1 | IMIDAZOL-4-YL-ETHYNYL-PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-21 | — | — | EP | disclosed |
| WO-2005006889-A1 | METHOD OF PROVIDING GRILL MARKS ON A FOODSTUFF | RED ARROW PRODUCTS COMPANY LLC (US) | 2005-01-27 | — | — | WO | disclosed |
| US-20040229917-A1 | Imidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-18 | — | — | US | disclosed |
| WO-2004080998-A1 | IMIDAZOL-4-YL-ETHYNYL-PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-23 | — | — | WO | disclosed |
| WO-1991005484-A1 | FAST PYROLYSIS LIQUID SMOKE | UNDERWOOD GARY L (US) | 1991-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317058-A1 | DEGRADABLE POLYMERS AND MONOMERS THEREFOR | HDHD5, LTA4H, KYNU | GRM5 2331/4885KCNH2 1289/4885FFAR1 11/4885 |
| US-20040229917-A1 | Imidazole derivatives | GRIK4, GRIA4, GRIK5 | GRM5 10/4885KCNH2 393/4885FFAR1 817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.