Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CMA1 | P23946 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 10/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4630336 | 0.77 | TAAR1 (0.47) | SLC6A2SLC6A4MAPTCRHR1LMNA | |
| SCHEMBL4629210 | 0.76 | KDM4E (0.31) | ALDH1A1KDM4E | |
| SCHEMBL12016021 | 0.62 | P2RX7 (0.45) | SLC6A2SLC6A4CMA1P2RX7NR1H2 | |
| SCHEMBL738218 | 0.62 | FFAR4 (0.40) | SLC6A2SLC6A4P2RX7 | |
| SCHEMBL488470 | 0.60 | P2RX7 (0.53) | SLC6A2SLC6A4P2RX7 | |
| SCHEMBL2632854 | 0.60 | P2RX7 (0.49) | SLC6A2SLC6A4P2RX7 | |
| SCHEMBL22232187 | 0.59 | ALDH1A1 (0.45) | SLC6A2SLC6A4MEN1KMT2AALDH1A1 | |
| SCHEMBL4630018 | 0.59 | KMT2A (0.39) | MEN1KMT2AALDH1A1MAPTP2RX7 | |
| SCHEMBL10540791 | 0.58 | P2RX7 (0.46) | SLC6A2SLC6A4P2RX7 | |
| SCHEMBL10747351 | 0.58 | P2RX7 (0.46) | SLC6A2SLC6A4P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981497-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | claimed |
| WO-2007085557-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | claimed |