SCHEMBL4630491

SCHEMBL4630491

Cc1cccc([NH3+])c1C.Fc1c(F)c(F)c([Al-](c2c(F)c(F)c(F)c(F)c2F)(c2c(F)c(F)c(F)c(F)c2F)c2c(F)c(F)c(F)c(F)c2F)c(F)c1F

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.33
ATM Q13315 1/20 0.33
ACHE P22303 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6694445 0.80 TRPA1 (0.41) TRPA1ATMACHE
SCHEMBL148465 0.78 TRPA1 (0.33) TRPA1ATMACHE
SCHEMBL28411487 0.76 TRPA1 (0.41) TRPA1ATMACHE
SCHEMBL4942420 0.73
SCHEMBL1240932 0.73
SCHEMBL5166755 0.72 TRPA1 (0.34) TRPA1ATMACHE
SCHEMBL7460565 0.71 ACHE (0.31) ACHE
SCHEMBL7455791 0.71 ACHE (0.31) ACHE
SCHEMBL5167013 0.70 RAPGEF4 (0.37) TRPA1ATMACHE
SCHEMBL17387194 0.70 ACHE (0.40) TRPA1ATMACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2004514033-A 2004-05-13 JP claimed
EP-1334137-A2 CATALYST SYSTEM AND ITS USE IN OLEFIN POLYMERIZATION Univation Technologies LLC (US) 2003-08-13 EP claimed
US-6605563-B1 Bulky ligand metallocene catalyst, an alumoxane activator, a Group 13 element containing first modifier, and a cycloalkadiene second modifier UNIVATION TECHNOLOGIES, LLC 2003-08-12 US claimed
US-20030149202-A1 CATALYST SYSTEM AND ITS USE IN OLEFIN POLYMERIZATION KAO SUN-CHUEH (US) 2003-08-07 US claimed
US-6552137-B1 Polymerization olefin(s) in the presence of a catalyst system comprising: bulky ligand metallocene catalyst compound; first modifier comprising a Group 13 element containing compound; second modifier comprising a cycloalkadiene and activator UNIVATION TECHNOLOGIES, LLC 2003-04-22 US claimed
WO-2002040555-A2 CATALYST SYSTEM AND ITS USE IN OLEFIN POLYMERIZATION UNIVATION TECHNOLOGIES, LLC (US) 2002-05-23 WO claimed
EP-3283536-B1 CATALYSTS FOR CONTROL OF LONG CHAIN BRANCHING UNIVATION TECH LLC (US) 2024-07-17 EP disclosed
US-20240150502-A1 BIPHENYLPHENOL POLYMERIZATION CATALYSTS DOW GLOBAL TECHNOLOGIES LLC (US) 2024-05-09 US disclosed
EP-3774931-B1 CONTROLLING A POLYMERIZATION REACTION UNIVATION TECH LLC (US) 2024-03-27 EP disclosed
EP-3663323-B1 PRODUCING POLYOLEFIN PRODUCTS UNIVATION TECH LLC (US) 2024-03-20 EP disclosed
US-20240076427-A1 PRODUCING POLYOLEFIN PRODUCTS UNIVATION TECHNOLOGIES, LLC (US) 2024-03-07 US disclosed
US-20240052075-A1 BIPHENYLPHENOL POLYMERIZATION CATALYSTS HAVING IMPROVED KINETIC INDUCTION TIMES DOW GLOBAL TECHNOLOGIES LLC (US) 2024-02-15 US disclosed
EP-4291585-A1 BIPHENYLPHENOL POLYMERIZATION CATALYSTS Dow Global Technologies LLC (US) 2023-12-20 EP disclosed
EP-1334137-A2 CATALYST SYSTEM AND ITS USE IN OLEFIN POLYMERIZATION Univation Technologies LLC (US) 2003-08-13 EP disclosed
US-6605563-B1 Bulky ligand metallocene catalyst, an alumoxane activator, a Group 13 element containing first modifier, and a cycloalkadiene second modifier UNIVATION TECHNOLOGIES, LLC 2003-08-12 US disclosed
US-20030149202-A1 CATALYST SYSTEM AND ITS USE IN OLEFIN POLYMERIZATION KAO SUN-CHUEH (US) 2003-08-07 US disclosed
US-6552137-B1 Polymerization olefin(s) in the presence of a catalyst system comprising: bulky ligand metallocene catalyst compound; first modifier comprising a Group 13 element containing compound; second modifier comprising a cycloalkadiene and activator UNIVATION TECHNOLOGIES, LLC 2003-04-22 US disclosed
WO-2002040555-A2 CATALYST SYSTEM AND ITS USE IN OLEFIN POLYMERIZATION UNIVATION TECHNOLOGIES, LLC (US) 2002-05-23 WO disclosed
WO-2002040549-A2 A METHOD FOR PREPARING A CATALYST COMPOSITION AND ITS USE IN A POLYMERIZATION PROCESS UNIVATION TECHNOLOGIES, LLC (US) 2002-05-23 WO disclosed
WO-1996013531-A1 PREPARATION OF MODIFIED POLYOLEFIN CATALYSTS AND IN SITU PREPARATION OF SUPPORTED METALLOCENE AND ZIEGLER-NATTA/METALLOCENE POLYOLEFIN CATALYSTS W.R. GRACE & CO.-CONN. (US) 1996-05-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240076427-A1 PRODUCING POLYOLEFIN PRODUCTS DNMT1, DNMT3B, DNMT3L TRPA1 4414/4885ATM 3682/4885ACHE 2913/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.