Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4629849 | 0.95 | GPR84 (0.42) | PPARAGPR84SOAT1 | |
| SCHEMBL4630629 | 0.94 | BID (0.43) | PPARAGPR84SOAT1 | |
| SCHEMBL4629945 | 0.90 | MAPT (0.39) | PPARA | |
| SCHEMBL4629941 | 0.84 | DPP4 (0.41) | — | |
| SCHEMBL27730914 | 0.83 | PSMB5 (0.42) | PSMB5PPARATLR8HSD11B1 | |
| SCHEMBL1765204 | 0.80 | TYR (0.54) | PSMB5 | |
| SCHEMBL11994132 | 0.80 | MC4R (0.46) | PSMB5 | |
| SCHEMBL28238287 | 0.80 | ADORA3 (0.45) | PSMB5HSD11B1 | |
| SCHEMBL29488620 | 0.80 | RARB (0.52) | — | |
| SCHEMBL15741313 | 0.80 | RARB (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919907-A2 | HETEROCYCLIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026959-A2 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | WO | disclosed |