Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 14/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | ESR1 | P03372 | 4/20 | 0.40 |
| ▸ | AR | P10275 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4630927 | 0.80 | HDAC6 (0.53) | VDRHDAC3HDAC6ESR1AR | |
| SCHEMBL4630971 | 0.76 | HDAC6 (0.57) | VDRHDAC3HDAC6AR | |
| SCHEMBL4507542 | 0.76 | VDR (0.62) | VDRHDAC3HDAC6 | |
| SCHEMBL16178304 | 0.74 | HDAC6 (0.76) | VDRHDAC3HDAC6AR | |
| SCHEMBL4631740 | 0.74 | HDAC6 (0.54) | VDRHDAC3HDAC6ESR1AR | |
| SCHEMBL4507917 | 0.73 | HDAC6 (0.67) | VDRHDAC3HDAC6AR | |
| SCHEMBL3395350 | 0.72 | HDAC6 (0.59) | VDRHDAC3HDAC6ESR1AR | |
| SCHEMBL16178148 | 0.72 | HDAC6 (1.00) | VDRHDAC3HDAC6ESR1 | |
| SCHEMBL16183027 | 0.72 | HDAC6 (0.71) | VDRHDAC3HDAC6ESR1AR | |
| SCHEMBL13709349 | 0.71 | HDAC6 (0.66) | VDRHDAC3HDAC6ESR1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7468449-B2 | Phenyl-furan compounds as vitamin D receptor modulators | ELI LILLY AND COMPANY (US) | 2008-12-23 | — | — | US | disclosed |
| US-7468449-B2 | Phenyl-furan compounds as vitamin D receptor modulators | ELI LILLY AND COMPANY (US) | 2008-12-23 | — | — | US | disclosed |
| US-7468449-B2 | Phenyl-furan compounds as vitamin D receptor modulators | ELI LILLY AND COMPANY (US) | 2008-12-23 | — | — | US | disclosed |
| EP-1692123-B1 | PHENYL-FURAN COMPOUNDS AS VITAMIN D RECEPTOR MODULATORS | LILLY CO ELI (US) | 2008-05-28 | — | — | EP | disclosed |
| EP-1692123-B1 | PHENYL-FURAN COMPOUNDS AS VITAMIN D RECEPTOR MODULATORS | LILLY CO ELI (US) | 2008-05-28 | — | — | EP | disclosed |
| US-20070105951-A1 | Phenyl-furan compounds as vitamin d receptor modulators | ELI LILLY AND COMPANY | 2007-05-10 | — | — | US | disclosed |
| US-20070105951-A1 | Phenyl-furan compounds as vitamin d receptor modulators | ELI LILLY AND COMPANY | 2007-05-10 | — | — | US | disclosed |
| US-20070105951-A1 | Phenyl-furan compounds as vitamin d receptor modulators | ELI LILLY AND COMPANY | 2007-05-10 | — | — | US | disclosed |
| EP-1692123-A1 | PHENYL-FURAN COMPOUNDS AS VITAMIN D RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005051936-A1 | PHENYL-FURAN COMPOUNDS AS VITAMIN D RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105951-A1 | Phenyl-furan compounds as vitamin d receptor modulators | VDR, CYP24A1, CYP2R1 | VDR 1/4885HDAC3 1918/4885HDAC6 4563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.