Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.54 |
| ▸ | VDR | P11473 | 12/20 | 0.51 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4630971 | 0.88 | HDAC6 (0.57) | HDAC6HDAC3VDRAR | |
| SCHEMBL4631780 | 0.84 | VDR (0.65) | VDRAR | |
| SCHEMBL4632569 | 0.82 | HDAC6 (0.57) | HDAC6HDAC3VDRAR | |
| SCHEMBL14199410 | 0.82 | HDAC6 (0.44) | HDAC6HDAC3VDRAR | |
| SCHEMBL13709370 | 0.81 | HDAC6 (0.63) | HDAC6HDAC3VDRESR1AR | |
| SCHEMBL4630974 | 0.79 | ESR1 (0.53) | VDRESR1AR | |
| SCHEMBL14199594 | 0.76 | NPC1 (0.37) | HDAC6HDAC3VDRESR1AR | |
| SCHEMBL4632300 | 0.75 | VDR (0.64) | HDAC6HDAC3VDRAR | |
| SCHEMBL4630924 | 0.74 | VDR (0.58) | HDAC6HDAC3VDRESR1AR | |
| SCHEMBL4630933 | 0.73 | HDAC6 (0.46) | HDAC6HDAC3VDRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7468449-B2 | Phenyl-furan compounds as vitamin D receptor modulators | ELI LILLY AND COMPANY (US) | 2008-12-23 | — | — | US | disclosed |
| US-7468449-B2 | Phenyl-furan compounds as vitamin D receptor modulators | ELI LILLY AND COMPANY (US) | 2008-12-23 | — | — | US | disclosed |
| EP-1692123-B1 | PHENYL-FURAN COMPOUNDS AS VITAMIN D RECEPTOR MODULATORS | LILLY CO ELI (US) | 2008-05-28 | — | — | EP | disclosed |
| EP-1692123-B1 | PHENYL-FURAN COMPOUNDS AS VITAMIN D RECEPTOR MODULATORS | LILLY CO ELI (US) | 2008-05-28 | — | — | EP | disclosed |
| US-20070105951-A1 | Phenyl-furan compounds as vitamin d receptor modulators | ELI LILLY AND COMPANY | 2007-05-10 | — | — | US | disclosed |
| US-20070105951-A1 | Phenyl-furan compounds as vitamin d receptor modulators | ELI LILLY AND COMPANY | 2007-05-10 | — | — | US | disclosed |
| US-20070105951-A1 | Phenyl-furan compounds as vitamin d receptor modulators | ELI LILLY AND COMPANY | 2007-05-10 | — | — | US | disclosed |
| EP-1692123-A1 | PHENYL-FURAN COMPOUNDS AS VITAMIN D RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005051936-A1 | PHENYL-FURAN COMPOUNDS AS VITAMIN D RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105951-A1 | Phenyl-furan compounds as vitamin d receptor modulators | VDR, CYP24A1, CYP2R1 | HDAC6 4563/4885HDAC3 1918/4885VDR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.