Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 13/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | FABP7 | O15540 | 2/20 | 0.34 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.34 |
| ▸ | MDM4 | O15151 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3489452 | 0.82 | DPP8 (0.40) | MDM2OPRD1FABP7FABP5MDM4 | |
| SCHEMBL3489451 | 0.78 | KDM1A (0.34) | MDM2FABP7FABP5MDM4TP53 | |
| SCHEMBL3015079 | 0.77 | KMT2A (0.42) | MDM2OPRD1OPRK1OPRM1FABP7 | |
| SCHEMBL3032315 | 0.76 | HSD11B1 (0.47) | MDM2FABP7FABP5TP53LMNA | |
| SCHEMBL3030476 | 0.76 | HSD11B1 (0.38) | MDM2FABP7FABP5SMN1; SMN2KMT2A | |
| SCHEMBL1256558 | 0.75 | OPRD1 (0.48) | OPRD1OPRK1OPRM1FABP7FABP5 | |
| SCHEMBL4630456 | 0.72 | OPRD1 (0.36) | MDM2OPRD1OPRK1OPRM1FABP7 | |
| SCHEMBL3015083 | 0.71 | MEN1 (0.43) | OPRD1OPRK1OPRM1FABP7FABP5 | |
| SCHEMBL28864147 | 0.71 | EPHX2 (0.44) | FABP7FABP5LMNASMN1; SMN2KMT2A | |
| SCHEMBL16004761 | 0.70 | POLB (0.46) | FABP7FABP5LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919875-A2 | PYRAZOLE DERIVATIVES AND THEIR USE AS PKA AND PKB MODULATORS | Astex Therapeutics Limited (GB) | 2008-05-14 | — | — | EP | disclosed |
| WO-2006136829-A2 | PYRAZOLE DERIVATIVES AND THEIR USE AS PKA AND PKB MODULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2006-12-28 | — | — | WO | disclosed |