Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 18/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.57 |
| ▸ | AR | P10275 | 3/20 | 0.57 |
| ▸ | VDR | P11473 | 1/20 | 0.45 |
| ▸ | ESRRG | P62508 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4630974 | 0.85 | ESR1 (0.53) | ESR1ESR2ARVDRESRRG | |
| SCHEMBL4664282 | 0.83 | RORC (0.51) | ESR1ESR2AR | |
| SCHEMBL3860357 | 0.76 | ESR1 (0.55) | ESR1ESR2ARVDR | |
| SCHEMBL837374 | 0.75 | ESR1 (1.00) | ESR1ESR2ARVDR | |
| SCHEMBL30058620 | 0.75 | ESR1 (1.00) | ESR1ESR2ARVDR | |
| SCHEMBL11346568 | 0.72 | ESR1 (0.66) | ESR1ESR2ARVDR | |
| SCHEMBL3858489 | 0.71 | ESR1 (0.51) | ESR1ESR2ARVDR | |
| SCHEMBL4630940 | 0.71 | TDP1 (0.44) | ESR1ESR2 | |
| SCHEMBL5971437 | 0.71 | ESR1 (0.81) | ESR1ESR2ARVDR | |
| SCHEMBL27782251 | 0.71 | TDP1 (0.44) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7468449-B2 | Phenyl-furan compounds as vitamin D receptor modulators | ELI LILLY AND COMPANY (US) | 2008-12-23 | — | — | US | disclosed |
| US-7468449-B2 | Phenyl-furan compounds as vitamin D receptor modulators | ELI LILLY AND COMPANY (US) | 2008-12-23 | — | — | US | disclosed |
| US-7468449-B2 | Phenyl-furan compounds as vitamin D receptor modulators | ELI LILLY AND COMPANY (US) | 2008-12-23 | — | — | US | disclosed |
| EP-1692123-B1 | PHENYL-FURAN COMPOUNDS AS VITAMIN D RECEPTOR MODULATORS | LILLY CO ELI (US) | 2008-05-28 | — | — | EP | disclosed |
| US-20070105951-A1 | Phenyl-furan compounds as vitamin d receptor modulators | ELI LILLY AND COMPANY | 2007-05-10 | — | — | US | disclosed |
| US-20070105951-A1 | Phenyl-furan compounds as vitamin d receptor modulators | ELI LILLY AND COMPANY | 2007-05-10 | — | — | US | disclosed |
| US-20070105951-A1 | Phenyl-furan compounds as vitamin d receptor modulators | ELI LILLY AND COMPANY | 2007-05-10 | — | — | US | disclosed |
| EP-1692123-A1 | PHENYL-FURAN COMPOUNDS AS VITAMIN D RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005051936-A1 | PHENYL-FURAN COMPOUNDS AS VITAMIN D RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105951-A1 | Phenyl-furan compounds as vitamin d receptor modulators | VDR, CYP24A1, CYP2R1 | ESR1 130/4885ESR2 142/4885AR 509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.